Expression of KDM4A in cancer - Summary

GENERAL INFORMATION
Gene name	KDM4A
Gene description	Lysine (K)-specific demethylase 4A
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in all tissues. Nuclear expression in neuronal cells and glandular cells of fallopian tube.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA007610
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA007610

GENE INFORMATION
Gene name	KDM4A (HGNC Symbol)
Synonyms	JHDM3A, JMJD2, JMJD2A, KIAA0677, TDRD14A
Description	Lysine (K)-specific demethylase 4A (HGNC Symbol)
Entrez gene summary	This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein containing a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form, and as a transcriptional repressor. [provided by RefSeq, Apr 2009]
Chromosome	1
Cytoband
Chromosome location (bp)	43650158 - 43705515
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000066135 (version 83.38)
Entrez gene	9682
UniProt	O75164 (UniProt - Evidence at protein level)
neXtProt	NX_O75164
Antibodypedia	KDM4A antibodies

PROTEIN BROWSER

KDM4A-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KDM4A-001 ENSP00000361473 ENST00000372396	O75164 [Direct mapping] Lysine-specific demethylase 4A Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005721 [pericentric heterochromatin] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0006281 [DNA repair] GO:0006302 [double-strand break repair] GO:0006325 [chromatin organization] GO:0006351 [transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0010507 [negative regulation of autophagy] GO:0010629 [negative regulation of gene expression] GO:0014898 [cardiac muscle hypertrophy in response to stress] GO:0016032 [viral process] GO:0016577 [histone demethylation] GO:0031625 [ubiquitin protein ligase binding] GO:0032452 [histone demethylase activity] GO:0035064 [methylated histone binding] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0051864 [histone demethylase activity (H3-K36 specific)] GO:0055114 [oxidation-reduction process] GO:0070544 [histone H3-K36 demethylation] GO:1900113 [negative regulation of histone H3-K9 trimethylation] Show all	1064 aa 120.7 kDa	No	0