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GOLGA5

GENERAL INFORMATION

Gene name

 GOLGA5

Gene description

 Golgin A5

Protein class

 Cancer-related genes
Disease related genes
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Granular cytoplasmic expression in all tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA000992 , HPA063876
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA000992
HPA063876

GENE INFORMATION

Gene name

 GOLGA5 (HGNC Symbol)

Synonyms

 golgin-84, GOLIM5, ret-II, rfg5

Description

 Golgin A5 (HGNC Symbol)

Entrez gene summary

 The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes one of the golgins, a family of proteins localized to the Golgi. This protein is a coiled-coil membrane protein that has been postulated to play a role in vesicle tethering and docking. Translocations involving this gene and the ret proto-oncogene have been found in tumor tissues; the chimeric sequences have been designated RET-II and PTC5. A pseudogene of this gene is located on the short arm of chromosome 5. [provided by RefSeq, Jul 2013]

Chromosome

 14

Cytoband

 q32.12

Chromosome location (bp)

 92794231 - 92839963

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000066455 (version 83.38)

Entrez gene

 9950

UniProt

 Q8TBA6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8TBA6

Antibodypedia

 GOLGA5 antibodies

PROTEIN BROWSER
GOLGA5-001
GOLGA5-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GOLGA5-001
ENSP00000163416
ENST00000163416
Q8TBA6 [Direct mapping]
Golgin subfamily A member 5
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
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GO:0000137 [Golgi cis cisterna]
GO:0000138 [Golgi trans cisterna]
GO:0000139 [Golgi membrane]
GO:0000301 [retrograde transport, vesicle recycling within Golgi]
GO:0005515 [protein binding]
GO:0005794 [Golgi apparatus]
GO:0005797 [Golgi medial cisterna]
GO:0005801 [cis-Golgi network]
GO:0007030 [Golgi organization]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0017137 [Rab GTPase binding]
GO:0030663 [COPI-coated vesicle membrane]
GO:0030674 [protein binding, bridging]
GO:0031985 [Golgi cisterna]
GO:0042803 [protein homodimerization activity]
GO:0048193 [Golgi vesicle transport]
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 731 aa
83 kDa 		No 1
GOLGA5-003
ENSP00000452601
ENST00000554700
H0YK03 [Direct mapping]
Golgin subfamily A member 5
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Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
 117 aa
12.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.