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ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP. It contains a Sec7 domain, which may be responsible for guanine-nucleotide exchange activity and also brefeldin A inhibition. [provided by RefSeq, Aug 2011]
MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000139 [Golgi membrane] GO:0005085 [guanyl-nucleotide exchange factor activity] GO:0005086 [ARF guanyl-nucleotide exchange factor activity] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005802 [trans-Golgi network] GO:0005829 [cytosol] GO:0006887 [exocytosis] GO:0007030 [Golgi organization] GO:0010256 [endomembrane system organization] GO:0015031 [protein transport] GO:0016363 [nuclear matrix] GO:0017022 [myosin binding] GO:0030532 [small nuclear ribonucleoprotein complex] GO:0030837 [negative regulation of actin filament polymerization] GO:0031175 [neuron projection development] GO:0032012 [regulation of ARF protein signal transduction] GO:0034237 [protein kinase A regulatory subunit binding] GO:0034260 [negative regulation of GTPase activity] GO:0043547 [positive regulation of GTPase activity] GO:0048471 [perinuclear region of cytoplasm] GO:0051897 [positive regulation of protein kinase B signaling] GO:0090284 [positive regulation of protein glycosylation in Golgi] GO:0090303 [positive regulation of wound healing] GO:2000114 [regulation of establishment of cell polarity]