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ARFGEF1

GENERAL INFORMATION

Gene name

 ARFGEF1

Gene description

 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA023399 , HPA023822
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and breast cancer (unfavourable).
Renal cancer p<0.001
Breast cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Testis cancer

STAINING SUMMARY
HPA023399
HPA023822

GENE INFORMATION

Gene name

 ARFGEF1 (HGNC Symbol)

Synonyms

 ARFGEP1, BIG1, DKFZP434L057, p200

Description

 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) (HGNC Symbol)

Entrez gene summary

 ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP. It contains a Sec7 domain, which may be responsible for guanine-nucleotide exchange activity and also brefeldin A inhibition. [provided by RefSeq, Aug 2011]

Chromosome

 8

Cytoband

 q13.2

Chromosome location (bp)

 67173511 - 67343677

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000066777 (version 83.38)

Entrez gene

 10565

UniProt

 Q9Y6D6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y6D6

Antibodypedia

 ARFGEF1 antibodies

PROTEIN BROWSER
ARFGEF1-001
ARFGEF1-002
ARFGEF1-003
ARFGEF1-007
ARFGEF1-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ARFGEF1-001
ENSP00000262215
ENST00000262215
Q9Y6D6 [Direct mapping]
Brefeldin A-inhibited guanine nucleotide-exchange protein 1
A0A024R7X0 [Target identity:100%; Query identity:100%]
ADP-ribosylation factor guanine nucleotide-exchange factor 1(Brefeldin A-inhibited), isoform CRA_a
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   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000139 [Golgi membrane]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005086 [ARF guanyl-nucleotide exchange factor activity]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005802 [trans-Golgi network]
GO:0005829 [cytosol]
GO:0006887 [exocytosis]
GO:0007030 [Golgi organization]
GO:0010256 [endomembrane system organization]
GO:0015031 [protein transport]
GO:0016363 [nuclear matrix]
GO:0017022 [myosin binding]
GO:0030532 [small nuclear ribonucleoprotein complex]
GO:0030837 [negative regulation of actin filament polymerization]
GO:0031175 [neuron projection development]
GO:0032012 [regulation of ARF protein signal transduction]
GO:0034237 [protein kinase A regulatory subunit binding]
GO:0034260 [negative regulation of GTPase activity]
GO:0043547 [positive regulation of GTPase activity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0090284 [positive regulation of protein glycosylation in Golgi]
GO:0090303 [positive regulation of wound healing]
GO:2000114 [regulation of establishment of cell polarity]
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 1849 aa
208.8 kDa 		No 0
ARFGEF1-002
ENSP00000429002
ENST00000519436
E5RJN9 [Direct mapping]
Brefeldin A-inhibited guanine nucleotide-exchange protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005086 [ARF guanyl-nucleotide exchange factor activity]
GO:0005802 [trans-Golgi network]
GO:0043547 [positive regulation of GTPase activity]
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 118 aa
13.1 kDa 		No 0
ARFGEF1-003
ENSP00000428429
ENST00000520381
E5RIF2 [Direct mapping]
Brefeldin A-inhibited guanine nucleotide-exchange protein 1
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   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005086 [ARF guanyl-nucleotide exchange factor activity]
GO:0005488 [binding]
GO:0005802 [trans-Golgi network]
GO:0032012 [regulation of ARF protein signal transduction]
GO:0043547 [positive regulation of GTPase activity]
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 1279 aa
145.5 kDa 		No 0
ARFGEF1-007
ENSP00000430891
ENST00000518230
E5RHL7 [Direct mapping]
Brefeldin A-inhibited guanine nucleotide-exchange protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005086 [ARF guanyl-nucleotide exchange factor activity]
GO:0005488 [binding]
GO:0005802 [trans-Golgi network]
GO:0043547 [positive regulation of GTPase activity]
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 825 aa
93.7 kDa 		No 0
ARFGEF1-010
ENSP00000429560
ENST00000518789
E5RHZ1 [Direct mapping]
Brefeldin A-inhibited guanine nucleotide-exchange protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005086 [ARF guanyl-nucleotide exchange factor activity]
GO:0005802 [trans-Golgi network]
GO:0043547 [positive regulation of GTPase activity]
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 192 aa
22.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.