Cell atlas - MYO9A - The Human Protein Atlas

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MYO9A

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Plasma membrane

Human cell
	Plasma Membrane

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GENERAL INFORMATION
Gene name	MYO9A
Gene description	Myosin IXA
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the plasma membrane.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA040071
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the plasma membrane.

Main location

Plasma membrane (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA040071	A-431	Plasma membrane
	HPA040071	U-2 OS	Plasma membrane
	HPA040071	U-251 MG	Plasma membrane

GENE INFORMATION
Gene name	MYO9A (HGNC Symbol)
Synonyms	FLJ11061, FLJ13244, MGC71859
Description	Myosin IXA (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the myosin superfamily. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-9 (MYH9). Unconventional myosins contain the basic domains of conventional myosins and are further distinguished from class members by their tail domains. They function as actin-based molecular motors. Mutations in this gene have been associated with Bardet-Biedl Syndrome. [provided by RefSeq, Dec 2011]
Chromosome	15
Cytoband	q23
Chromosome location (bp)	71822289 - 72118577
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000066933 (version 83.38)
Entrez gene	4649
UniProt	B2RTY4 (UniProt - Evidence at protein level)
neXtProt	NX_B2RTY4
Antibodypedia	MYO9A antibodies

PROTEIN BROWSER

MYO9A-001	MYO9A-002	MYO9A-004	MYO9A-007	MYO9A-015	MYO9A-017	MYO9A-018	MYO9A-019	MYO9A-201	MYO9A-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MYO9A-001 ENSP00000348349 ENST00000356056	B2RTY4 [Direct mapping] Unconventional myosin-IXa Show all	Phobius predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003774 [motor activity] GO:0003779 [actin binding] GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005829 [cytosol] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0007601 [visual perception] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016459 [myosin complex] GO:0016461 [unconventional myosin complex] GO:0035556 [intracellular signal transduction] GO:0043547 [positive regulation of GTPase activity] GO:0046872 [metal ion binding] GO:0051056 [regulation of small GTPase mediated signal transduction] Show all	2548 aa 292.7 kDa	No	0
MYO9A-002 ENSP00000454446 ENST00000566885	H3BMM1 [Direct mapping] Unconventional myosin-IXa Show all	THUMBUP predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003774 [motor activity] GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0008152 [metabolic process] GO:0016459 [myosin complex] GO:0035556 [intracellular signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	1301 aa 150.2 kDa	No	0
MYO9A-004 ENSP00000457945 ENST00000561618	H3BV44 [Direct mapping] Unconventional myosin-IXa Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005622 [intracellular] GO:0007165 [signal transduction] GO:0035556 [intracellular signal transduction] Show all	1398 aa 157.9 kDa	No	0
MYO9A-007 ENSP00000457407 ENST00000568042	H3BU05 [Direct mapping] Unconventional myosin-IXa Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0007165 [signal transduction] Show all	463 aa 51.9 kDa	No	0
MYO9A-015 ENSP00000456192 ENST00000564571	H3BRD5 [Direct mapping] Unconventional myosin-IXa Show all	Phobius predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003774 [motor activity] GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0007165 [signal transduction] GO:0008152 [metabolic process] GO:0016459 [myosin complex] GO:0035556 [intracellular signal transduction] GO:0043547 [positive regulation of GTPase activity] GO:0046872 [metal ion binding] Show all	2396 aa 276 kDa	No	0
MYO9A-017 ENSP00000455150 ENST00000568481	H3BP49 [Direct mapping] Unconventional myosin-IXa Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003774 [motor activity] GO:0005096 [GTPase activator activity] GO:0005622 [intracellular] GO:0007165 [signal transduction] GO:0008152 [metabolic process] GO:0035556 [intracellular signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	194 aa 22 kDa	No	0
MYO9A-018 ENSP00000456882 ENST00000564931	H3BSU8 [Direct mapping] Unconventional myosin-IXa Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0007165 [signal transduction] Show all	73 aa 8.2 kDa	No	0
MYO9A-019 ENSP00000454517 ENST00000569314	H3BMS3 [Direct mapping] Unconventional myosin-IXa Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003774 [motor activity] GO:0005096 [GTPase activator activity] GO:0005622 [intracellular] GO:0007165 [signal transduction] GO:0008152 [metabolic process] GO:0035556 [intracellular signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	141 aa 16.5 kDa	No	0
MYO9A-201 ENSP00000399162 ENST00000424560	B2RTY4 [Direct mapping] Unconventional myosin-IXa Show all	Phobius predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003774 [motor activity] GO:0003779 [actin binding] GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005829 [cytosol] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0007601 [visual perception] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016459 [myosin complex] GO:0016461 [unconventional myosin complex] GO:0043547 [positive regulation of GTPase activity] GO:0046872 [metal ion binding] GO:0051056 [regulation of small GTPase mediated signal transduction] Show all	729 aa 84.7 kDa	No	0
MYO9A-202 ENSP00000398250 ENST00000444904	B2RTY4 [Direct mapping] Unconventional myosin-IXa Show all	Phobius predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003774 [motor activity] GO:0003779 [actin binding] GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005829 [cytosol] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0007601 [visual perception] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016459 [myosin complex] GO:0016461 [unconventional myosin complex] GO:0035556 [intracellular signal transduction] GO:0043547 [positive regulation of GTPase activity] GO:0046872 [metal ion binding] GO:0051056 [regulation of small GTPase mediated signal transduction] Show all	2548 aa 292.7 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.