Fields »
ABOUT
HELP
BLOG
MYO9A

GENERAL INFORMATION

Gene name

 MYO9A

Gene description

 Myosin IXA

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 10
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Expressed in all
HPA (normal tissue):Tissue enhanced (testis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 External characterization data supports antibody staining. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA039812 , HPA040071
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA039812
HPA040071

GENE INFORMATION

Gene name

 MYO9A (HGNC Symbol)

Synonyms

 FLJ11061, FLJ13244, MGC71859

Description

 Myosin IXA (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the myosin superfamily. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-9 (MYH9). Unconventional myosins contain the basic domains of conventional myosins and are further distinguished from class members by their tail domains. They function as actin-based molecular motors. Mutations in this gene have been associated with Bardet-Biedl Syndrome. [provided by RefSeq, Dec 2011]

Chromosome

 15

Cytoband

 q23

Chromosome location (bp)

 71822289 - 72118577

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000066933 (version 83.38)

Entrez gene

 4649

UniProt

 B2RTY4 (UniProt - Evidence at protein level)

neXtProt

 NX_B2RTY4

Antibodypedia

 MYO9A antibodies

PROTEIN BROWSER
MYO9A-001
MYO9A-002
MYO9A-004
MYO9A-007
MYO9A-015
MYO9A-017
MYO9A-018
MYO9A-019
MYO9A-201
MYO9A-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MYO9A-001
ENSP00000348349
ENST00000356056
B2RTY4 [Direct mapping]
Unconventional myosin-IXa
Show all
   Phobius predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003774 [motor activity]
GO:0003779 [actin binding]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007601 [visual perception]
GO:0008152 [metabolic process]
GO:0016021 [integral component of membrane]
GO:0016459 [myosin complex]
GO:0016461 [unconventional myosin complex]
GO:0035556 [intracellular signal transduction]
GO:0043547 [positive regulation of GTPase activity]
GO:0046872 [metal ion binding]
GO:0051056 [regulation of small GTPase mediated signal transduction]
Show all
 2548 aa
292.7 kDa 		No 0
MYO9A-002
ENSP00000454446
ENST00000566885
H3BMM1 [Direct mapping]
Unconventional myosin-IXa
Show all
   THUMBUP predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003774 [motor activity]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0008152 [metabolic process]
GO:0016459 [myosin complex]
GO:0035556 [intracellular signal transduction]
GO:0043547 [positive regulation of GTPase activity]
Show all
 1301 aa
150.2 kDa 		No 0
MYO9A-004
ENSP00000457945
ENST00000561618
H3BV44 [Direct mapping]
Unconventional myosin-IXa
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005622 [intracellular]
GO:0007165 [signal transduction]
GO:0035556 [intracellular signal transduction]
Show all
 1398 aa
157.9 kDa 		No 0
MYO9A-007
ENSP00000457407
ENST00000568042
H3BU05 [Direct mapping]
Unconventional myosin-IXa
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007165 [signal transduction]
Show all
 463 aa
51.9 kDa 		No 0
MYO9A-015
ENSP00000456192
ENST00000564571
H3BRD5 [Direct mapping]
Unconventional myosin-IXa
Show all
   Phobius predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003774 [motor activity]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0007165 [signal transduction]
GO:0008152 [metabolic process]
GO:0016459 [myosin complex]
GO:0035556 [intracellular signal transduction]
GO:0043547 [positive regulation of GTPase activity]
GO:0046872 [metal ion binding]
Show all
 2396 aa
276 kDa 		No 0
MYO9A-017
ENSP00000455150
ENST00000568481
H3BP49 [Direct mapping]
Unconventional myosin-IXa
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003774 [motor activity]
GO:0005096 [GTPase activator activity]
GO:0005622 [intracellular]
GO:0007165 [signal transduction]
GO:0008152 [metabolic process]
GO:0035556 [intracellular signal transduction]
GO:0043547 [positive regulation of GTPase activity]
Show all
 194 aa
22 kDa 		No 0
MYO9A-018
ENSP00000456882
ENST00000564931
H3BSU8 [Direct mapping]
Unconventional myosin-IXa
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007165 [signal transduction]
Show all
 73 aa
8.2 kDa 		No 0
MYO9A-019
ENSP00000454517
ENST00000569314
H3BMS3 [Direct mapping]
Unconventional myosin-IXa
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003774 [motor activity]
GO:0005096 [GTPase activator activity]
GO:0005622 [intracellular]
GO:0007165 [signal transduction]
GO:0008152 [metabolic process]
GO:0035556 [intracellular signal transduction]
GO:0043547 [positive regulation of GTPase activity]
Show all
 141 aa
16.5 kDa 		No 0
MYO9A-201
ENSP00000399162
ENST00000424560
B2RTY4 [Direct mapping]
Unconventional myosin-IXa
Show all
   Phobius predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003774 [motor activity]
GO:0003779 [actin binding]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007601 [visual perception]
GO:0008152 [metabolic process]
GO:0016021 [integral component of membrane]
GO:0016459 [myosin complex]
GO:0016461 [unconventional myosin complex]
GO:0043547 [positive regulation of GTPase activity]
GO:0046872 [metal ion binding]
GO:0051056 [regulation of small GTPase mediated signal transduction]
Show all
 729 aa
84.7 kDa 		No 0
MYO9A-202
ENSP00000398250
ENST00000444904
B2RTY4 [Direct mapping]
Unconventional myosin-IXa
Show all
   Phobius predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003774 [motor activity]
GO:0003779 [actin binding]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007601 [visual perception]
GO:0008152 [metabolic process]
GO:0016021 [integral component of membrane]
GO:0016459 [myosin complex]
GO:0016461 [unconventional myosin complex]
GO:0035556 [intracellular signal transduction]
GO:0043547 [positive regulation of GTPase activity]
GO:0046872 [metal ion binding]
GO:0051056 [regulation of small GTPase mediated signal transduction]
Show all
 2548 aa
292.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.