Fields »
ABOUT
HELP
BLOG
IDI1

GENERAL INFORMATION

Gene name

 IDI1

Gene description

 Isopentenyl-diphosphate delta isomerase 1

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA039169
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA039169

GENE INFORMATION

Gene name

 IDI1

Synonyms

Description

 Isopentenyl-diphosphate delta isomerase 1 (HGNC Symbol)

Entrez gene summary

 IDI1 encodes a peroxisomally-localized enzyme that catalyzes the interconversion of isopentenyl diphosphate (IPP) to its highly electrophilic isomer, dimethylallyl diphosphate (DMAPP), which are the substrates for the successive reaction that results in the synthesis of farnesyl diphosphate and, ultimately, cholesterol. It has been shown in peroxisomal deficiency diseases such as Zellweger syndrome and neonatal adrenoleukodystrophy that there is reduction in IPP isomerase activity. [provided by RefSeq, Jul 2008]

Chromosome

 10

Cytoband

 p15.3

Chromosome location (bp)

 1039908 - 1049170

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000067064 (version 83.38)

Entrez gene

 3422

UniProt

 Q13907 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13907

Antibodypedia

 IDI1 antibodies

PROTEIN BROWSER
IDI1-002
IDI1-003
IDI1-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IDI1-002
ENSP00000401879
ENST00000429642
C9JKM8 [Direct mapping]
Isopentenyl-diphosphate Delta-isomerase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004452 [isopentenyl-diphosphate delta-isomerase activity]
GO:0008299 [isoprenoid biosynthetic process]
GO:0016787 [hydrolase activity]
Show all
 122 aa
13.8 kDa 		No 0
IDI1-003
ENSP00000404771
ENST00000427898
C9JD53 [Direct mapping]
Isopentenyl-diphosphate Delta-isomerase 1
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004452 [isopentenyl-diphosphate delta-isomerase activity]
GO:0008299 [isoprenoid biosynthetic process]
GO:0016787 [hydrolase activity]
Show all
 120 aa
13.7 kDa 		No 0
IDI1-004
ENSP00000370748
ENST00000381344
Q13907 [Direct mapping]
Isopentenyl-diphosphate Delta-isomerase 1
Show all
Enzymes
   ENZYME proteins
   Isomerase
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0004452 [isopentenyl-diphosphate delta-isomerase activity]
GO:0005777 [peroxisome]
GO:0005829 [cytosol]
GO:0006695 [cholesterol biosynthetic process]
GO:0008299 [isoprenoid biosynthetic process]
GO:0016787 [hydrolase activity]
GO:0030145 [manganese ion binding]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0050992 [dimethylallyl diphosphate biosynthetic process]
Show all
 284 aa
32.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.