Expression of PLPP1 in cancer - Summary

GENERAL INFORMATION
Gene name	PLPP1
Gene description	Phospholipid phosphatase 1
Protein class	Enzymes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (HMC-1)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Membranous and cytoplasmic expression in most tissues, highly abundant in prostate glands.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Supported based on 1 antibody. HPA047815
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PROGNOSTIC SUMMARY
Prognostic marker in stomach cancer (unfavourable) and liver cancer (favourable).
Stomach cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA047815

GENE INFORMATION
Gene name	PLPP1 (HGNC Symbol)
Synonyms	LPP1, PAP-2a, PPAP2A
Description	Phospholipid phosphatase 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in synthesis of glycerolipids and in phospholipase D-mediated signal transduction. This enzyme is an integral membrane glycoprotein that plays a role in the hydrolysis and uptake of lipids from extracellular space. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]
Chromosome	5
Cytoband	q11.2
Chromosome location (bp)	55424854 - 55535050
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000067113 (version 83.38)
Entrez gene	8611
UniProt	O14494 (UniProt - Evidence at protein level)
neXtProt	NX_O14494
Antibodypedia	PLPP1 antibodies

PROTEIN BROWSER

PLPP1-001	PLPP1-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PLPP1-001 ENSP00000264775 ENST00000264775	O14494 [Direct mapping] Lipid phosphate phosphohydrolase 1 A0A024QZU7 [Target identity:100%; Query identity:100%] Phosphatidic acid phosphatase type 2A, isoform CRA_b Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006629 [lipid metabolic process] GO:0006644 [phospholipid metabolic process] GO:0006665 [sphingolipid metabolic process] GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway] GO:0008195 [phosphatidate phosphatase activity] GO:0008285 [negative regulation of cell proliferation] GO:0008354 [germ cell migration] GO:0016020 [membrane] GO:0019216 [regulation of lipid metabolic process] GO:0030148 [sphingolipid biosynthetic process] GO:0030518 [intracellular steroid hormone receptor signaling pathway] GO:0030521 [androgen receptor signaling pathway] GO:0042577 [lipid phosphatase activity] GO:0044281 [small molecule metabolic process] GO:0046839 [phospholipid dephosphorylation] GO:0070062 [extracellular exosome] Show all	285 aa 32.1 kDa	No	6
PLPP1-002 ENSP00000302229 ENST00000307259	O14494 [Direct mapping] Lipid phosphate phosphohydrolase 1 A0A024QZS3 [Target identity:100%; Query identity:100%] Phosphatidic acid phosphatase type 2A, isoform CRA_a Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006629 [lipid metabolic process] GO:0006644 [phospholipid metabolic process] GO:0006665 [sphingolipid metabolic process] GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway] GO:0008195 [phosphatidate phosphatase activity] GO:0008285 [negative regulation of cell proliferation] GO:0008354 [germ cell migration] GO:0016020 [membrane] GO:0019216 [regulation of lipid metabolic process] GO:0030148 [sphingolipid biosynthetic process] GO:0030518 [intracellular steroid hormone receptor signaling pathway] GO:0030521 [androgen receptor signaling pathway] GO:0042577 [lipid phosphatase activity] GO:0044281 [small molecule metabolic process] GO:0046839 [phospholipid dephosphorylation] GO:0070062 [extracellular exosome] Show all	284 aa 32.2 kDa	No	6