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PLPP1

GENERAL INFORMATION

Gene name

 PLPP1

Gene description

 Phospholipid phosphatase 1

Protein class

 Enzymes
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Membranous and cytoplasmic expression in most tissues, highly abundant in prostate glands.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 1 antibody.
HPA047815
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Nasopharynx
N/A
N/A
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Prostate

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 PLPP1 (HGNC Symbol)

Synonyms

 LPP1, PAP-2a, PPAP2A

Description

 Phospholipid phosphatase 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in synthesis of glycerolipids and in phospholipase D-mediated signal transduction. This enzyme is an integral membrane glycoprotein that plays a role in the hydrolysis and uptake of lipids from extracellular space. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]

Chromosome

 5

Cytoband

 q11.2

Chromosome location (bp)

 55424854 - 55535050

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000067113 (version 83.38)

Entrez gene

 8611

UniProt

 O14494 (UniProt - Evidence at protein level)

neXtProt

 NX_O14494

Antibodypedia

 PLPP1 antibodies

PROTEIN BROWSER
PLPP1-001
PLPP1-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PLPP1-001
ENSP00000264775
ENST00000264775
O14494 [Direct mapping]
Lipid phosphate phosphohydrolase 1
A0A024QZU7 [Target identity:100%; Query identity:100%]
Phosphatidic acid phosphatase type 2A, isoform CRA_b
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006629 [lipid metabolic process]
GO:0006644 [phospholipid metabolic process]
GO:0006665 [sphingolipid metabolic process]
GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway]
GO:0008195 [phosphatidate phosphatase activity]
GO:0008285 [negative regulation of cell proliferation]
GO:0008354 [germ cell migration]
GO:0016020 [membrane]
GO:0019216 [regulation of lipid metabolic process]
GO:0030148 [sphingolipid biosynthetic process]
GO:0030518 [intracellular steroid hormone receptor signaling pathway]
GO:0030521 [androgen receptor signaling pathway]
GO:0042577 [lipid phosphatase activity]
GO:0044281 [small molecule metabolic process]
GO:0046839 [phospholipid dephosphorylation]
GO:0070062 [extracellular exosome]
Show all
 285 aa
32.1 kDa 		No 6
PLPP1-002
ENSP00000302229
ENST00000307259
O14494 [Direct mapping]
Lipid phosphate phosphohydrolase 1
A0A024QZS3 [Target identity:100%; Query identity:100%]
Phosphatidic acid phosphatase type 2A, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006629 [lipid metabolic process]
GO:0006644 [phospholipid metabolic process]
GO:0006665 [sphingolipid metabolic process]
GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway]
GO:0008195 [phosphatidate phosphatase activity]
GO:0008285 [negative regulation of cell proliferation]
GO:0008354 [germ cell migration]
GO:0016020 [membrane]
GO:0019216 [regulation of lipid metabolic process]
GO:0030148 [sphingolipid biosynthetic process]
GO:0030518 [intracellular steroid hormone receptor signaling pathway]
GO:0030521 [androgen receptor signaling pathway]
GO:0042577 [lipid phosphatase activity]
GO:0044281 [small molecule metabolic process]
GO:0046839 [phospholipid dephosphorylation]
GO:0070062 [extracellular exosome]
Show all
 284 aa
32.2 kDa 		No 6

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.