Expression of DNTTIP2 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

DNTTIP2

premium

TISSUE

premium

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	DNTTIP2
Gene description	Deoxynucleotidyltransferase, terminal, interacting protein 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nucleolar expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA044502 , HPA053707
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and renal cancer (unfavourable).
Liver cancer p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA044502	HPA053707

GENE INFORMATION
Gene name	DNTTIP2 (HGNC Symbol)
Synonyms	ERBP, HSU15552, TdIF2
Description	Deoxynucleotidyltransferase, terminal, interacting protein 2 (HGNC Symbol)
Entrez gene summary	This gene is thought to be involved in chromatin remodeling and gene transcription. The encoded nuclear protein binds to and enhances the transcriptional activity of the estrogen receptor alpha, and also interacts with terminal deoxynucleotidyltransferase. The expression profile of this gene is a potential biomarker for chronic obstructive pulmonary disease. [provided by RefSeq, Dec 2010]
Chromosome	1
Cytoband	p22.1
Chromosome location (bp)	93866283 - 93879918
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000067334 (version 83.38)
Entrez gene	30836
UniProt	Q5QJE6 (UniProt - Evidence at protein level)
neXtProt	NX_Q5QJE6
Antibodypedia	DNTTIP2 antibodies

PROTEIN BROWSER

DNTTIP2-001	DNTTIP2-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DNTTIP2-001 ENSP00000411010 ENST00000436063	Q5QJE6 [Direct mapping] Deoxynucleotidyltransferase terminal-interacting protein 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0044822 [poly(A) RNA binding] Show all	756 aa 84.5 kDa	No	0
DNTTIP2-008 ENSP00000434261 ENST00000528680	E9PRB3 [Direct mapping] Deoxynucleotidyltransferase terminal-interacting protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		161 aa 17.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.