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SYT1

GENERAL INFORMATION

Gene name

 SYT1

Gene description

 Synaptotagmin I

Protein class

 Disease related genes
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins
Transporters

Predicted localization

 Intracellular,Membrane

Number of transcripts

 10
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (cerebral cortex)
GTEx:Group enriched (caudate, cerebellum, cerebral cortex, hippocampus, hypothalamus)
FANTOM5:Group enriched (brain, caudate, cerebellum, hippocampus)

Protein evidence

 Evidence at protein level

Protein expression

 Selective expression in neuropil in CNS.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA008394 , HPA064788
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (caudate, cerebellum, cerebral cortex, hippocampus, hypothalamus)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (brain, caudate, cerebellum, hippocampus)

GENE INFORMATION

Gene name

 SYT1 (HGNC Symbol)

Synonyms

 P65, SVP65, SYT

Description

 Synaptotagmin I (HGNC Symbol)

Entrez gene summary

 The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin-1 participates in triggering neurotransmitter release at the synapse (Fernandez-Chacon et al., 2001 [PubMed 11242035]).[supplied by OMIM, Jul 2010]

Chromosome

 12

Cytoband

 q21.2

Chromosome location (bp)

 78863993 - 79452008

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000067715 (version 83.38)

Entrez gene

 6857

UniProt

 P21579 (UniProt - Evidence at protein level)

neXtProt

 NX_P21579

Antibodypedia

 SYT1 antibodies

PROTEIN BROWSER
SYT1-001
SYT1-002
SYT1-003
SYT1-004
SYT1-005
SYT1-007
SYT1-009
SYT1-010
SYT1-011
SYT1-012

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SYT1-001
ENSP00000261205
ENST00000261205
P21579 [Direct mapping]
Synaptotagmin-1
A0A024RBE9 [Target identity:100%; Query identity:100%]
Synaptotagmin I, isoform CRA_a
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000149 [SNARE binding]
GO:0001786 [phosphatidylserine binding]
GO:0005509 [calcium ion binding]
GO:0005513 [detection of calcium ion]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005543 [phospholipid binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005545 [1-phosphatidylinositol binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005886 [plasma membrane]
GO:0007268 [synaptic transmission]
GO:0007269 [neurotransmitter secretion]
GO:0007420 [brain development]
GO:0008021 [synaptic vesicle]
GO:0008022 [protein C-terminus binding]
GO:0014047 [glutamate secretion]
GO:0016021 [integral component of membrane]
GO:0016079 [synaptic vesicle exocytosis]
GO:0017075 [syntaxin-1 binding]
GO:0017157 [regulation of exocytosis]
GO:0017158 [regulation of calcium ion-dependent exocytosis]
GO:0019905 [syntaxin binding]
GO:0030054 [cell junction]
GO:0030141 [secretory granule]
GO:0030276 [clathrin binding]
GO:0030672 [synaptic vesicle membrane]
GO:0031045 [dense core granule]
GO:0031201 [SNARE complex]
GO:0031340 [positive regulation of vesicle fusion]
GO:0042584 [chromaffin granule membrane]
GO:0042734 [presynaptic membrane]
GO:0042802 [identical protein binding]
GO:0043005 [neuron projection]
GO:0043195 [terminal bouton]
GO:0043229 [intracellular organelle]
GO:0045956 [positive regulation of calcium ion-dependent exocytosis]
GO:0048278 [vesicle docking]
GO:0048306 [calcium-dependent protein binding]
GO:0048488 [synaptic vesicle endocytosis]
GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter]
GO:0050750 [low-density lipoprotein particle receptor binding]
GO:0050806 [positive regulation of synaptic transmission]
GO:0051260 [protein homooligomerization]
GO:0051592 [response to calcium ion]
GO:0051966 [regulation of synaptic transmission, glutamatergic]
GO:0060076 [excitatory synapse]
GO:0060201 [clathrin-sculpted acetylcholine transport vesicle membrane]
GO:0060203 [clathrin-sculpted glutamate transport vesicle membrane]
GO:0061202 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
GO:0070083 [clathrin-sculpted monoamine transport vesicle membrane]
GO:0098746 [fast, calcium ion-dependent exocytosis of neurotransmitter]
GO:1903305 [regulation of regulated secretory pathway]
GO:1903861 [positive regulation of dendrite extension]
Show all
 422 aa
47.6 kDa 		No 1
SYT1-002
ENSP00000376932
ENST00000393240
P21579 [Direct mapping]
Synaptotagmin-1
A0A024RBE9 [Target identity:100%; Query identity:100%]
Synaptotagmin I, isoform CRA_a
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000149 [SNARE binding]
GO:0005509 [calcium ion binding]
GO:0005513 [detection of calcium ion]
GO:0005515 [protein binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005545 [1-phosphatidylinositol binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005886 [plasma membrane]
GO:0007268 [synaptic transmission]
GO:0007269 [neurotransmitter secretion]
GO:0008021 [synaptic vesicle]
GO:0014047 [glutamate secretion]
GO:0016021 [integral component of membrane]
GO:0016079 [synaptic vesicle exocytosis]
GO:0017075 [syntaxin-1 binding]
GO:0017157 [regulation of exocytosis]
GO:0017158 [regulation of calcium ion-dependent exocytosis]
GO:0030054 [cell junction]
GO:0030276 [clathrin binding]
GO:0030672 [synaptic vesicle membrane]
GO:0042584 [chromaffin granule membrane]
GO:0043005 [neuron projection]
GO:0048488 [synaptic vesicle endocytosis]
GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter]
GO:0050750 [low-density lipoprotein particle receptor binding]
GO:0050806 [positive regulation of synaptic transmission]
GO:0051260 [protein homooligomerization]
GO:0051966 [regulation of synaptic transmission, glutamatergic]
GO:0060201 [clathrin-sculpted acetylcholine transport vesicle membrane]
GO:0060203 [clathrin-sculpted glutamate transport vesicle membrane]
GO:0061202 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
GO:0070083 [clathrin-sculpted monoamine transport vesicle membrane]
GO:0098746 [fast, calcium ion-dependent exocytosis of neurotransmitter]
GO:1903305 [regulation of regulated secretory pathway]
GO:1903861 [positive regulation of dendrite extension]
Show all
 422 aa
47.6 kDa 		No 1
SYT1-003
ENSP00000401559
ENST00000446242
C9JX50 [Direct mapping]
Synaptotagmin-1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005886 [plasma membrane]
GO:0016021 [integral component of membrane]
GO:0016079 [synaptic vesicle exocytosis]
GO:0017158 [regulation of calcium ion-dependent exocytosis]
GO:0030276 [clathrin binding]
GO:0030672 [synaptic vesicle membrane]
GO:0048488 [synaptic vesicle endocytosis]
GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter]
Show all
 182 aa
19.9 kDa 		No 1
SYT1-004
ENSP00000391056
ENST00000457153
J3KQA0 [Direct mapping]
Synaptotagmin I, isoform CRA_b; Synaptotagmin-1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005886 [plasma membrane]
GO:0016021 [integral component of membrane]
GO:0016079 [synaptic vesicle exocytosis]
GO:0017158 [regulation of calcium ion-dependent exocytosis]
GO:0030276 [clathrin binding]
GO:0030672 [synaptic vesicle membrane]
GO:0048488 [synaptic vesicle endocytosis]
GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter]
Show all
 419 aa
47.3 kDa 		No 1
SYT1-005
ENSP00000447575
ENST00000552744
P21579 [Direct mapping]
Synaptotagmin-1
A0A024RBE9 [Target identity:100%; Query identity:100%]
Synaptotagmin I, isoform CRA_a
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000149 [SNARE binding]
GO:0005509 [calcium ion binding]
GO:0005513 [detection of calcium ion]
GO:0005515 [protein binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005545 [1-phosphatidylinositol binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005886 [plasma membrane]
GO:0007268 [synaptic transmission]
GO:0007269 [neurotransmitter secretion]
GO:0008021 [synaptic vesicle]
GO:0014047 [glutamate secretion]
GO:0016021 [integral component of membrane]
GO:0016079 [synaptic vesicle exocytosis]
GO:0017075 [syntaxin-1 binding]
GO:0017157 [regulation of exocytosis]
GO:0017158 [regulation of calcium ion-dependent exocytosis]
GO:0030054 [cell junction]
GO:0030276 [clathrin binding]
GO:0030672 [synaptic vesicle membrane]
GO:0042584 [chromaffin granule membrane]
GO:0043005 [neuron projection]
GO:0048488 [synaptic vesicle endocytosis]
GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter]
GO:0050750 [low-density lipoprotein particle receptor binding]
GO:0050806 [positive regulation of synaptic transmission]
GO:0051260 [protein homooligomerization]
GO:0051966 [regulation of synaptic transmission, glutamatergic]
GO:0060201 [clathrin-sculpted acetylcholine transport vesicle membrane]
GO:0060203 [clathrin-sculpted glutamate transport vesicle membrane]
GO:0061202 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
GO:0070083 [clathrin-sculpted monoamine transport vesicle membrane]
GO:0098746 [fast, calcium ion-dependent exocytosis of neurotransmitter]
GO:1903305 [regulation of regulated secretory pathway]
GO:1903861 [positive regulation of dendrite extension]
Show all
 422 aa
47.6 kDa 		No 1
SYT1-007
ENSP00000447035
ENST00000552074
F8W1U9 [Direct mapping]
Synaptotagmin-1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005886 [plasma membrane]
GO:0016021 [integral component of membrane]
GO:0016079 [synaptic vesicle exocytosis]
GO:0017158 [regulation of calcium ion-dependent exocytosis]
GO:0030276 [clathrin binding]
GO:0030672 [synaptic vesicle membrane]
GO:0048488 [synaptic vesicle endocytosis]
GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter]
Show all
 94 aa
10.2 kDa 		No 1
SYT1-009
ENSP00000448964
ENST00000547046
F8VYH8 [Direct mapping]
Synaptotagmin-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005886 [plasma membrane]
GO:0016079 [synaptic vesicle exocytosis]
GO:0017158 [regulation of calcium ion-dependent exocytosis]
GO:0030276 [clathrin binding]
GO:0030672 [synaptic vesicle membrane]
GO:0048488 [synaptic vesicle endocytosis]
GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter]
Show all
 58 aa
6.2 kDa 		No 0
SYT1-010
ENSP00000450321
ENST00000549671
A0A0E3D6M2 [Direct mapping]
Synaptotagmin-1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
 72 aa
7.6 kDa 		No 1
SYT1-011
ENSP00000447656
ENST00000551304
F8VZY3 [Direct mapping]
Synaptotagmin-1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005886 [plasma membrane]
GO:0016021 [integral component of membrane]
GO:0016079 [synaptic vesicle exocytosis]
GO:0017158 [regulation of calcium ion-dependent exocytosis]
GO:0030276 [clathrin binding]
GO:0030672 [synaptic vesicle membrane]
GO:0048488 [synaptic vesicle endocytosis]
GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter]
Show all
 73 aa
7.7 kDa 		No 1
SYT1-012
ENSP00000448861
ENST00000552624
F8VXH0 [Direct mapping]
Synaptotagmin-1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005886 [plasma membrane]
GO:0016021 [integral component of membrane]
GO:0016079 [synaptic vesicle exocytosis]
GO:0017158 [regulation of calcium ion-dependent exocytosis]
GO:0030276 [clathrin binding]
GO:0030672 [synaptic vesicle membrane]
GO:0048488 [synaptic vesicle endocytosis]
GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter]
Show all
 174 aa
19 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.