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OTUD5

GENERAL INFORMATION

Gene name

 OTUD5

Gene description

 OTU deubiquitinase 5

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Group enriched (U-266/70, U-266/84)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA017375
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PROGNOSTIC SUMMARY
Prognostic marker in lung cancer (favourable), pancreatic cancer (favourable) and cervical cancer (favourable).
Lung cancer p<0.001
Pancreatic cancer p<0.001
Cervical cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA017375

GENE INFORMATION

Gene name

 OTUD5 (HGNC Symbol)

Synonyms

 DKFZp761A052, DUBA

Description

 OTU deubiquitinase 5 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU domain confers deubiquitinase activity and the encoded protein has been shown to suppress the type I interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling complex and disruption of the type I interferon signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Oct 2008]

Chromosome

 X

Cytoband

 p11.23

Chromosome location (bp)

 48922028 - 48958386

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000068308 (version 83.38)

Entrez gene

 55593

UniProt

 Q96G74 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96G74

Antibodypedia

 OTUD5 antibodies

PROTEIN BROWSER
OTUD5-002
OTUD5-003
OTUD5-004
OTUD5-006
OTUD5-201
OTUD5-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
OTUD5-002
ENSP00000390767
ENST00000455452
H7BZQ3 [Direct mapping]
OTU domain-containing protein 5
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0004843 [ubiquitin-specific protease activity]
GO:0016579 [protein deubiquitination]
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 444 aa
48.9 kDa 		No 0
OTUD5-003
ENSP00000156084
ENST00000156084
Q96G74 [Direct mapping]
OTU domain-containing protein 5
A0A024QZ09 [Target identity:100%; Query identity:100%]
OTU domain containing 5, isoform CRA_d
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Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004843 [ubiquitin-specific protease activity]
GO:0005829 [cytosol]
GO:0032480 [negative regulation of type I interferon production]
GO:0032496 [response to lipopolysaccharide]
GO:0045087 [innate immune response]
GO:0070536 [protein K63-linked deubiquitination]
GO:0071108 [protein K48-linked deubiquitination]
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 571 aa
60.6 kDa 		No 0
OTUD5-004
ENSP00000365671
ENST00000376488
Q96G74 [Direct mapping]
OTU domain-containing protein 5
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Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004843 [ubiquitin-specific protease activity]
GO:0005829 [cytosol]
GO:0032480 [negative regulation of type I interferon production]
GO:0032496 [response to lipopolysaccharide]
GO:0045087 [innate immune response]
GO:0070536 [protein K63-linked deubiquitination]
GO:0071108 [protein K48-linked deubiquitination]
Show all
 566 aa
60.2 kDa 		No 0
OTUD5-006
ENSP00000401629
ENST00000428668
Q96G74 [Direct mapping]
OTU domain-containing protein 5
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004843 [ubiquitin-specific protease activity]
GO:0005829 [cytosol]
GO:0032480 [negative regulation of type I interferon production]
GO:0032496 [response to lipopolysaccharide]
GO:0045087 [innate immune response]
GO:0070536 [protein K63-linked deubiquitination]
GO:0071108 [protein K48-linked deubiquitination]
Show all
 349 aa
39.2 kDa 		No 0
OTUD5-201
ENSP00000379969
ENST00000396743
Q96G74 [Direct mapping]
OTU domain-containing protein 5
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Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004843 [ubiquitin-specific protease activity]
GO:0005829 [cytosol]
GO:0032480 [negative regulation of type I interferon production]
GO:0032496 [response to lipopolysaccharide]
GO:0045087 [innate immune response]
GO:0070536 [protein K63-linked deubiquitination]
GO:0071108 [protein K48-linked deubiquitination]
Show all
 566 aa
60.2 kDa 		No 0
OTUD5-202
ENSP00000481335
ENST00000610466
A0A087WXV6 [Direct mapping]
OTU domain-containing protein 5
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   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004843 [ubiquitin-specific protease activity]
GO:0016579 [protein deubiquitination]
Show all
 542 aa
58 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.