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This gene encodes a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU domain confers deubiquitinase activity and the encoded protein has been shown to suppress the type I interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling complex and disruption of the type I interferon signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Oct 2008]
Q96G74 [Direct mapping] OTU domain-containing protein 5 A0A024QZ09 [Target identity:100%; Query identity:100%] OTU domain containing 5, isoform CRA_d
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Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0004843 [ubiquitin-specific protease activity] GO:0005829 [cytosol] GO:0032480 [negative regulation of type I interferon production] GO:0032496 [response to lipopolysaccharide] GO:0045087 [innate immune response] GO:0070536 [protein K63-linked deubiquitination] GO:0071108 [protein K48-linked deubiquitination]
Q96G74 [Direct mapping] OTU domain-containing protein 5
Show all
Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004843 [ubiquitin-specific protease activity] GO:0005829 [cytosol] GO:0032480 [negative regulation of type I interferon production] GO:0032496 [response to lipopolysaccharide] GO:0045087 [innate immune response] GO:0070536 [protein K63-linked deubiquitination] GO:0071108 [protein K48-linked deubiquitination]
Q96G74 [Direct mapping] OTU domain-containing protein 5
Show all
Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004843 [ubiquitin-specific protease activity] GO:0005829 [cytosol] GO:0032480 [negative regulation of type I interferon production] GO:0032496 [response to lipopolysaccharide] GO:0045087 [innate immune response] GO:0070536 [protein K63-linked deubiquitination] GO:0071108 [protein K48-linked deubiquitination]
