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ACSL4

GENERAL INFORMATION

Gene name

 ACSL4

Gene description

 Acyl-CoA synthetase long-chain family member 4

Protein class

 Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (HMC-1)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA005552
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PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (favourable).
Urothelial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA005552

GENE INFORMATION

Gene name

 ACSL4 (HGNC Symbol)

Synonyms

 ACS4, FACL4, LACS4, MRX63, MRX68

Description

 Acyl-CoA synthetase long-chain family member 4 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme preferentially utilizes arachidonate as substrate. The absence of this enzyme may contribute to the mental retardation or Alport syndrome. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]

Chromosome

 X

Cytoband

 q23

Chromosome location (bp)

 109624244 - 109733403

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000068366 (version 83.38)

Entrez gene

 2182

UniProt

 O60488 (UniProt - Evidence at protein level)

neXtProt

 NX_O60488

Antibodypedia

 ACSL4 antibodies

PROTEIN BROWSER
ACSL4-001
ACSL4-002
ACSL4-003
ACSL4-006
ACSL4-007
ACSL4-008
ACSL4-009
ACSL4-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ACSL4-001
ENSP00000262835
ENST00000348502
O60488 [Direct mapping]
Long-chain-fatty-acid--CoA ligase 4
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Enzymes
   ENZYME proteins
   Ligase
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001676 [long-chain fatty acid metabolic process]
GO:0003824 [catalytic activity]
GO:0004467 [long-chain fatty acid-CoA ligase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005741 [mitochondrial outer membrane]
GO:0005778 [peroxisomal membrane]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005811 [lipid particle]
GO:0006629 [lipid metabolic process]
GO:0008152 [metabolic process]
GO:0008610 [lipid biosynthetic process]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019432 [triglyceride biosynthetic process]
GO:0030307 [positive regulation of cell growth]
GO:0031957 [very long-chain fatty acid-CoA ligase activity]
GO:0032307 [negative regulation of prostaglandin secretion]
GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process]
GO:0044233 [ER-mitochondrion membrane contact site]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0047676 [arachidonate-CoA ligase activity]
GO:0070062 [extracellular exosome]
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 670 aa
74.4 kDa 		No 0
ACSL4-002
ENSP00000423077
ENST00000469857
A0A0C4DGB7 [Direct mapping]
Long-chain-fatty-acid--CoA ligase 4
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
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GO:0016021 [integral component of membrane]
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 54 aa
6.2 kDa 		No 1
ACSL4-003
ENSP00000419171
ENST00000469796
O60488 [Direct mapping]
Long-chain-fatty-acid--CoA ligase 4
Show all
Enzymes
   ENZYME proteins
   Ligase
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001676 [long-chain fatty acid metabolic process]
GO:0003824 [catalytic activity]
GO:0004467 [long-chain fatty acid-CoA ligase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005741 [mitochondrial outer membrane]
GO:0005778 [peroxisomal membrane]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005811 [lipid particle]
GO:0006629 [lipid metabolic process]
GO:0008152 [metabolic process]
GO:0008610 [lipid biosynthetic process]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019432 [triglyceride biosynthetic process]
GO:0030307 [positive regulation of cell growth]
GO:0031957 [very long-chain fatty acid-CoA ligase activity]
GO:0032307 [negative regulation of prostaglandin secretion]
GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process]
GO:0044233 [ER-mitochondrion membrane contact site]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0047676 [arachidonate-CoA ligase activity]
GO:0070062 [extracellular exosome]
Show all
 711 aa
79.2 kDa 		No 3
ACSL4-006
ENSP00000425378
ENST00000508092
D6RDA8 [Direct mapping]
Long-chain-fatty-acid--CoA ligase 4
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016021 [integral component of membrane]
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 128 aa
14.6 kDa 		No 1
ACSL4-007
ENSP00000425408
ENST00000502391
D6RD96 [Direct mapping]
Long-chain-fatty-acid--CoA ligase 4
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016021 [integral component of membrane]
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 145 aa
16.4 kDa 		No 1
ACSL4-008
ENSP00000424808
ENST00000505855
D6RF95 [Direct mapping]
Long-chain-fatty-acid--CoA ligase 4
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0008152 [metabolic process]
Show all
 154 aa
17.2 kDa 		No 0
ACSL4-009
ENSP00000421425
ENST00000504980
D6RFW9 [Direct mapping]
Long-chain-fatty-acid--CoA ligase 4
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016021 [integral component of membrane]
Show all
 126 aa
14.3 kDa 		No 1
ACSL4-201
ENSP00000339787
ENST00000340800
O60488 [Direct mapping]
Long-chain-fatty-acid--CoA ligase 4
Show all
Enzymes
   ENZYME proteins
   Ligase
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001676 [long-chain fatty acid metabolic process]
GO:0003824 [catalytic activity]
GO:0004467 [long-chain fatty acid-CoA ligase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005777 [peroxisome]
GO:0005778 [peroxisomal membrane]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005811 [lipid particle]
GO:0006629 [lipid metabolic process]
GO:0006641 [triglyceride metabolic process]
GO:0007584 [response to nutrient]
GO:0008152 [metabolic process]
GO:0008610 [lipid biosynthetic process]
GO:0015908 [fatty acid transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019432 [triglyceride biosynthetic process]
GO:0030182 [neuron differentiation]
GO:0030307 [positive regulation of cell growth]
GO:0031957 [very long-chain fatty acid-CoA ligase activity]
GO:0031966 [mitochondrial membrane]
GO:0032307 [negative regulation of prostaglandin secretion]
GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process]
GO:0043025 [neuronal cell body]
GO:0044233 [ER-mitochondrion membrane contact site]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0047676 [arachidonate-CoA ligase activity]
GO:0060136 [embryonic process involved in female pregnancy]
GO:0060996 [dendritic spine development]
GO:0070062 [extracellular exosome]
GO:0070672 [response to interleukin-15]
Show all
 711 aa
79.2 kDa 		No 3

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.