Expression of GRIPAP1 in cancer - Summary - The Human Protein Atlas

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GRIPAP1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	GRIPAP1
Gene description	GRIP1 associated protein 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues at variable levels.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 2 antibodies. HPA000282 , HPA000615
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and urothelial cancer (favourable).
Renal cancer p<0.001 Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA000282	HPA000615

GENE INFORMATION
Gene name	GRIPAP1 (HGNC Symbol)
Synonyms	DKFZp434P0630, GRASP-1, GRASP1, KIAA1167, MPMGp800B12492Q3
Description	GRIP1 associated protein 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a guanine nucleotide exchange factor for the Ras family of small G proteins (RasGEF). The encoded protein interacts in a complex with glutamate receptor interacting protein 1 (GRIP1) and plays a role in the regulation of AMPA receptor function. [provided by RefSeq, Aug 2013]
Chromosome	X
Cytoband	p11.23
Chromosome location (bp)	48973720 - 49002264
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000068400 (version 83.38)
Entrez gene	56850
UniProt	Q4V328 (UniProt - Evidence at protein level)
neXtProt	NX_Q4V328
Antibodypedia	GRIPAP1 antibodies

PROTEIN BROWSER

GRIPAP1-001	GRIPAP1-005	GRIPAP1-006	GRIPAP1-010	GRIPAP1-011	GRIPAP1-014	GRIPAP1-015

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GRIPAP1-001 ENSP00000365606 ENST00000376423	Q4V328 [Direct mapping] GRIP1-associated protein 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005769 [early endosome] GO:0008150 [biological_process] GO:0072562 [blood microparticle] Show all	841 aa 96 kDa	No	0
GRIPAP1-005 ENSP00000469842 ENST00000593475	A0A075B793 [Direct mapping] GRIP1-associated protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		810 aa 92.8 kDa	No	0
GRIPAP1-006 ENSP00000477574 ENST00000622599	A0A087WT45 [Direct mapping] GRIP1-associated protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		796 aa 90.9 kDa	No	0
GRIPAP1-010 ENSP00000480856 ENST00000619107	A0A087WXA6 [Direct mapping] GRIP1-associated protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		302 aa 35 kDa	No	0
GRIPAP1-011 ENSP00000482629 ENST00000622231	A0A087WZF5 [Direct mapping] GRIP1-associated protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		121 aa 13.5 kDa	No	0
GRIPAP1-014 ENSP00000479263 ENST00000611705	A0A087WV84 [Direct mapping] GRIP1-associated protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		23 aa 2.7 kDa	No	0
GRIPAP1-015 ENSP00000480042 ENST00000617369	A0A087WW92 [Direct mapping] GRIP1-associated protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		70 aa 7.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.