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ATP11A

GENERAL INFORMATION

Gene name

 ATP11A

Gene description

 ATPase, class VI, type 11A

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Membranous and cytoplasmic expression in several tissues, including kidney.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA035583 , HPA035584
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Renal cancer

STAINING SUMMARY
HPA035583
HPA035584

GENE INFORMATION

Gene name

 ATP11A (HGNC Symbol)

Synonyms

 ATPIH, ATPIS, KIAA1021

Description

 ATPase, class VI, type 11A (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is an integral membrane ATPase. The encoded protein is probably phosphorylated in its intermediate state and likely drives the transport of ions such as calcium across membranes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 13

Cytoband

 q34

Chromosome location (bp)

 112690329 - 112887168

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000068650 (version 83.38)

Entrez gene

 23250

UniProt

 P98196 (UniProt - Evidence at protein level)

neXtProt

 NX_P98196

Antibodypedia

 ATP11A antibodies

PROTEIN BROWSER
ATP11A-001
ATP11A-003
ATP11A-004
ATP11A-010
ATP11A-014
ATP11A-201
ATP11A-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ATP11A-001
ENSP00000420387
ENST00000487903
P98196 [Direct mapping]
Probable phospholipid-transporting ATPase IH
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000287 [magnesium ion binding]
GO:0004012 [phospholipid-translocating ATPase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005765 [lysosomal membrane]
GO:0005769 [early endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005886 [plasma membrane]
GO:0008152 [metabolic process]
GO:0015914 [phospholipid transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045332 [phospholipid translocation]
GO:0046872 [metal ion binding]
GO:0055037 [recycling endosome]
Show all
 1134 aa
129.8 kDa 		No >9
ATP11A-003
ENSP00000396374
ENST00000418678
H0Y547 [Direct mapping]
Phospholipid-transporting ATPase
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000287 [magnesium ion binding]
GO:0004012 [phospholipid-translocating ATPase activity]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0008152 [metabolic process]
GO:0015914 [phospholipid transport]
GO:0016021 [integral component of membrane]
GO:0045332 [phospholipid translocation]
GO:0046872 [metal ion binding]
Show all
 935 aa
106.5 kDa 		No 6
ATP11A-004
ENSP00000410824
ENST00000419631
A2A3G9 [Direct mapping]
Probable phospholipid-transporting ATPase IH
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0004012 [phospholipid-translocating ATPase activity]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0016021 [integral component of membrane]
GO:0045332 [phospholipid translocation]
Show all
 183 aa
20.7 kDa 		No 2
ATP11A-010
ENSP00000402575
ENST00000415301
H0Y624 [Direct mapping]
Probable phospholipid-transporting ATPase IH
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0004012 [phospholipid-translocating ATPase activity]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0016021 [integral component of membrane]
GO:0045332 [phospholipid translocation]
Show all
 75 aa
8.3 kDa 		No 0
ATP11A-014
ENSP00000479392
ENST00000610419
A0A087WVE8 [Direct mapping]
Probable phospholipid-transporting ATPase IH
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0004012 [phospholipid-translocating ATPase activity]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0016021 [integral component of membrane]
GO:0045332 [phospholipid translocation]
Show all
 62 aa
6.9 kDa 		No 0
ATP11A-201
ENSP00000364781
ENST00000375630
E9PEJ6 [Direct mapping]
Phospholipid-transporting ATPase
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000287 [magnesium ion binding]
GO:0004012 [phospholipid-translocating ATPase activity]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0008152 [metabolic process]
GO:0015914 [phospholipid transport]
GO:0016021 [integral component of membrane]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045332 [phospholipid translocation]
GO:0046872 [metal ion binding]
Show all
 1191 aa
135.8 kDa 		No >9
ATP11A-202
ENSP00000364796
ENST00000375645
P98196 [Direct mapping]
Probable phospholipid-transporting ATPase IH
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000287 [magnesium ion binding]
GO:0004012 [phospholipid-translocating ATPase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005765 [lysosomal membrane]
GO:0005769 [early endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005886 [plasma membrane]
GO:0008152 [metabolic process]
GO:0015914 [phospholipid transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045332 [phospholipid translocation]
GO:0046872 [metal ion binding]
GO:0055037 [recycling endosome]
Show all
 1134 aa
129.8 kDa 		No >9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.