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LAPTM4A

GENERAL INFORMATION

Gene name

 LAPTM4A

Gene description

 Lysosomal protein transmembrane 4 alpha

Protein class

 Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA031402 , HPA031404
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 LAPTM4A (HGNC Symbol)

Synonyms

 HUMORF13, KIAA0108, LAPTM4, MBNT, Mtrp

Description

 Lysosomal protein transmembrane 4 alpha (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that has four predicted transmembrane domains. The function of this gene has not yet been determined; however, studies in the mouse homolog suggest a role in the transport of small molecules across endosomal and lysosomal membranes. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 p24.1

Chromosome location (bp)

 20032650 - 20052028

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000068697 (version 83.38)

Entrez gene

 9741

UniProt

 Q15012 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15012

Antibodypedia

 LAPTM4A antibodies

PROTEIN BROWSER
LAPTM4A-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LAPTM4A-001
ENSP00000175091
ENST00000175091
Q15012 [Direct mapping]
Lysosomal-associated transmembrane protein 4A
Q6IBP4 [Target identity:100%; Query identity:100%]
LAPTM4A protein; Lysosomal protein transmembrane 4 alpha; Lysosomal-associated protein transmembrane 4 alpha, isoform CRA_b
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005794 [Golgi apparatus]
GO:0006810 [transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
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 233 aa
26.8 kDa 		No 4

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.