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KIF2A

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GENERAL INFORMATION

Gene name

 KIF2A

Gene description

 Kinesin heavy chain member 2A

Protein class

 Cancer-related genes
Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleus, nucleoli & centrosome.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleus (validated), Nucleoli (validated), Centrosome (validated)

Single-cell variation

 Single-cell variation in protein expression observed.

GFP

 The location(s) are Validated based on analysis of GFP-tagged protein.

DATA RELIABILITY

Reliability score

 Validated based on 1 antibody.
HPA004715
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ASSAYS
RNA expression
Human cells
GFP

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleus, nucleoli & centrosome.

Main location

 Nucleus (validated), Nucleoli (validated), Centrosome (validated)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA004715 A549 Nucleus
Nucleoli
Centrosome
HPA004715 RH-30 Nucleus
Nucleoli
Centrosome
HPA004715 U-2 OS Nucleus Spatial
Nuclear bodies Spatial
Centrosome

GFP

Antibody

 HPA004715

Validation

C-terminal tag
BAC cell line: 6513
Validated: Antibody staining overlaps with GFP tagged protein

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

BAC id

Tag

Location antibody staining

Location tagged protein
HPA004715 HeLa 6513 C-terminal Nucleus, Nucleoli, Centrosome, Cytosol Nucleus, Centrosome, Cytosol
HPA004715 HeLa Normal - Nucleus, Nucleoli, Centrosome, Cytosol -

GENE INFORMATION

Gene name

 KIF2A (HGNC Symbol)

Synonyms

 HK2, KIF2

Description

 Kinesin heavy chain member 2A (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a plus end-directed motor required for normal mitotic progression. The encoded protein is required for normal spindle activity during mitosis and is necessary for normal brain development. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

Chromosome

 5

Cytoband

 q12.1

Chromosome location (bp)

 62306162 - 62537249

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000068796 (version 83.38)

Entrez gene

 3796

UniProt

 O00139 (UniProt - Evidence at protein level)

neXtProt

 NX_O00139

Antibodypedia

 KIF2A antibodies

PROTEIN BROWSER
KIF2A-001
KIF2A-002
KIF2A-003
KIF2A-004
KIF2A-005
KIF2A-006
KIF2A-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KIF2A-001
ENSP00000370493
ENST00000381103
O00139 [Direct mapping]
Kinesin-like protein KIF2A
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000922 [spindle pole]
GO:0003774 [motor activity]
GO:0003777 [microtubule motor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005871 [kinesin complex]
GO:0005876 [spindle microtubule]
GO:0007018 [microtubule-based movement]
GO:0007019 [microtubule depolymerization]
GO:0007052 [mitotic spindle organization]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007399 [nervous system development]
GO:0007596 [blood coagulation]
GO:0008017 [microtubule binding]
GO:0008152 [metabolic process]
GO:0016020 [membrane]
GO:0016887 [ATPase activity]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0030154 [cell differentiation]
GO:0051301 [cell division]
GO:0090307 [mitotic spindle assembly]
Show all
 686 aa
77.7 kDa 		No 0
KIF2A-002
ENSP00000385000
ENST00000407818
O00139 [Direct mapping]
Kinesin-like protein KIF2A
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000922 [spindle pole]
GO:0003774 [motor activity]
GO:0003777 [microtubule motor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005871 [kinesin complex]
GO:0005876 [spindle microtubule]
GO:0007018 [microtubule-based movement]
GO:0007019 [microtubule depolymerization]
GO:0007052 [mitotic spindle organization]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007399 [nervous system development]
GO:0007596 [blood coagulation]
GO:0008017 [microtubule binding]
GO:0008152 [metabolic process]
GO:0016020 [membrane]
GO:0016887 [ATPase activity]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0030154 [cell differentiation]
GO:0051301 [cell division]
GO:0090307 [mitotic spindle assembly]
GO:0097228 [sperm principal piece]
Show all
 744 aa
84.1 kDa 		No 0
KIF2A-003
ENSP00000385622
ENST00000401507
O00139 [Direct mapping]
Kinesin-like protein KIF2A
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000922 [spindle pole]
GO:0003774 [motor activity]
GO:0003777 [microtubule motor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005871 [kinesin complex]
GO:0005876 [spindle microtubule]
GO:0007018 [microtubule-based movement]
GO:0007019 [microtubule depolymerization]
GO:0007052 [mitotic spindle organization]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007399 [nervous system development]
GO:0007596 [blood coagulation]
GO:0008017 [microtubule binding]
GO:0008152 [metabolic process]
GO:0016020 [membrane]
GO:0016887 [ATPase activity]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0030154 [cell differentiation]
GO:0051301 [cell division]
GO:0090307 [mitotic spindle assembly]
Show all
 706 aa
80 kDa 		No 0
KIF2A-004
ENSP00000425411
ENST00000512541
D6RD93 [Direct mapping]
Kinesin-like protein KIF2A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003777 [microtubule motor activity]
GO:0005871 [kinesin complex]
GO:0007018 [microtubule-based movement]
GO:0007019 [microtubule depolymerization]
GO:0016887 [ATPase activity]
Show all
 80 aa
8.8 kDa 		No 0
KIF2A-005
ENSP00000423772
ENST00000506857
O00139 [Direct mapping]
Kinesin-like protein KIF2A
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000922 [spindle pole]
GO:0003774 [motor activity]
GO:0003777 [microtubule motor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005871 [kinesin complex]
GO:0005876 [spindle microtubule]
GO:0007018 [microtubule-based movement]
GO:0007019 [microtubule depolymerization]
GO:0007052 [mitotic spindle organization]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007399 [nervous system development]
GO:0007596 [blood coagulation]
GO:0008017 [microtubule binding]
GO:0008152 [metabolic process]
GO:0016020 [membrane]
GO:0016887 [ATPase activity]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0030154 [cell differentiation]
GO:0051301 [cell division]
GO:0090307 [mitotic spindle assembly]
Show all
 660 aa
75 kDa 		No 0
KIF2A-006
ENSP00000423542
ENST00000514082
D6R9M0 [Direct mapping]
Kinesin-like protein KIF2A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003777 [microtubule motor activity]
GO:0005524 [ATP binding]
GO:0005871 [kinesin complex]
GO:0007018 [microtubule-based movement]
GO:0007019 [microtubule depolymerization]
GO:0008017 [microtubule binding]
GO:0008152 [metabolic process]
GO:0016887 [ATPase activity]
Show all
 284 aa
32.7 kDa 		No 0
KIF2A-009
ENSP00000421041
ENST00000512006
H0Y8H2 [Direct mapping]
Kinesin-like protein KIF2A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003777 [microtubule motor activity]
GO:0005524 [ATP binding]
GO:0005871 [kinesin complex]
GO:0007018 [microtubule-based movement]
GO:0007019 [microtubule depolymerization]
GO:0008017 [microtubule binding]
GO:0008152 [metabolic process]
GO:0016887 [ATPase activity]
Show all
 130 aa
14.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.