Cell atlas - RASGRP2 - The Human Protein Atlas

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RASGRP2

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	RASGRP2
Gene description	RAS guanyl releasing protein 2 (calcium and DAG-regulated)
Protein class	Disease related genes Plasma proteins Predicted intracellular proteins RAS pathway related proteins
Predicted localization	Intracellular
Number of transcripts	14
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Cell line enhanced (NB-4, HL-60, REH, HEL)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (NB-4, HL-60, REH, HEL) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	RASGRP2 (HGNC Symbol)
Synonyms	CALDAG-GEFI
Description	RAS guanyl releasing protein 2 (calcium and DAG-regulated) (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a brain-enriched nucleotide exchanged factor that contains an N-terminal GEF domain, 2 tandem repeats of EF-hand calcium-binding motifs, and a C-terminal diacylglycerol/phorbol ester-binding domain. This protein can activate small GTPases, including RAS and RAP1/RAS3. The nucleotide exchange activity of this protein can be stimulated by calcium and diacylglycerol. Three alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	11
Cytoband	q13.1
Chromosome location (bp)	64726911 - 64745456
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000068831 (version 83.38)
Entrez gene	10235
UniProt	Q7LDG7 (UniProt - Evidence at protein level)
neXtProt	NX_Q7LDG7
Antibodypedia	RASGRP2 antibodies

PROTEIN BROWSER

RASGRP2-001	RASGRP2-002	RASGRP2-003	RASGRP2-005	RASGRP2-007	RASGRP2-008	RASGRP2-009	RASGRP2-010	RASGRP2-011	RASGRP2-012	RASGRP2-013	RASGRP2-014	RASGRP2-016	RASGRP2-022

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RASGRP2-001 ENSP00000377953 ENST00000394432	Q7LDG7 [Direct mapping] RAS guanyl-releasing protein 2 Show all	Predicted intracellular proteins Plasma proteins RAS pathway related proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001558 [regulation of cell growth] GO:0005085 [guanyl-nucleotide exchange factor activity] GO:0005509 [calcium ion binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007596 [blood coagulation] GO:0008289 [lipid binding] GO:0019992 [diacylglycerol binding] GO:0030054 [cell junction] GO:0030168 [platelet activation] GO:0032587 [ruffle membrane] GO:0035556 [intracellular signal transduction] GO:0043005 [neuron projection] GO:0043547 [positive regulation of GTPase activity] GO:0045202 [synapse] GO:0071277 [cellular response to calcium ion] Show all	609 aa 69.2 kDa	No	0
RASGRP2-002 ENSP00000338864 ENST00000354024	Q7LDG7 [Direct mapping] RAS guanyl-releasing protein 2 Show all	Predicted intracellular proteins Plasma proteins RAS pathway related proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001558 [regulation of cell growth] GO:0005085 [guanyl-nucleotide exchange factor activity] GO:0005509 [calcium ion binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007596 [blood coagulation] GO:0008289 [lipid binding] GO:0019992 [diacylglycerol binding] GO:0030054 [cell junction] GO:0030168 [platelet activation] GO:0032587 [ruffle membrane] GO:0035556 [intracellular signal transduction] GO:0043005 [neuron projection] GO:0043547 [positive regulation of GTPase activity] GO:0045202 [synapse] GO:0071277 [cellular response to calcium ion] Show all	609 aa 69.2 kDa	No	0
RASGRP2-003 ENSP00000366717 ENST00000377497	Q7LDG7 [Direct mapping] RAS guanyl-releasing protein 2 Show all	Predicted intracellular proteins Plasma proteins RAS pathway related proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001558 [regulation of cell growth] GO:0005085 [guanyl-nucleotide exchange factor activity] GO:0005509 [calcium ion binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007596 [blood coagulation] GO:0008289 [lipid binding] GO:0019992 [diacylglycerol binding] GO:0030054 [cell junction] GO:0030168 [platelet activation] GO:0032587 [ruffle membrane] GO:0035556 [intracellular signal transduction] GO:0043005 [neuron projection] GO:0043547 [positive regulation of GTPase activity] GO:0045202 [synapse] GO:0071277 [cellular response to calcium ion] Show all	609 aa 69.2 kDa	No	0
RASGRP2-005 ENSP00000377951 ENST00000394430	A6NJ28 [Direct mapping] RAS guanyl-releasing protein 2 Show all	Predicted intracellular proteins RAS pathway related proteins Protein evidence (Ezkurdia et al 2014) Show all		148 aa 16.6 kDa	No	0
RASGRP2-007 ENSP00000366714 ENST00000377494	Q7LDG7 [Direct mapping] RAS guanyl-releasing protein 2 Show all	Predicted intracellular proteins Plasma proteins RAS pathway related proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0001558 [regulation of cell growth] GO:0005085 [guanyl-nucleotide exchange factor activity] GO:0005509 [calcium ion binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007596 [blood coagulation] GO:0008289 [lipid binding] GO:0019992 [diacylglycerol binding] GO:0030054 [cell junction] GO:0030168 [platelet activation] GO:0032587 [ruffle membrane] GO:0035556 [intracellular signal transduction] GO:0043005 [neuron projection] GO:0043547 [positive regulation of GTPase activity] GO:0045202 [synapse] GO:0071277 [cellular response to calcium ion] Show all	610 aa 69.3 kDa	No	0
RASGRP2-008 ENSP00000366709 ENST00000377489	A6NJ28 [Direct mapping] RAS guanyl-releasing protein 2 Show all	Predicted intracellular proteins RAS pathway related proteins Protein evidence (Ezkurdia et al 2014) Show all		148 aa 16.6 kDa	No	0
RASGRP2-009 ENSP00000366707 ENST00000377487	A6NJ28 [Direct mapping] RAS guanyl-releasing protein 2 Show all	Predicted intracellular proteins RAS pathway related proteins Protein evidence (Ezkurdia et al 2014) Show all		148 aa 16.6 kDa	No	0
RASGRP2-010 ENSP00000366706 ENST00000377486	A6NJ28 [Direct mapping] RAS guanyl-releasing protein 2 Show all	Predicted intracellular proteins RAS pathway related proteins Protein evidence (Ezkurdia et al 2014) Show all		148 aa 16.6 kDa	No	0
RASGRP2-011 ENSP00000377950 ENST00000394429	A8MTF9 [Direct mapping] RAS guanyl-releasing protein 2 Show all	Predicted intracellular proteins RAS pathway related proteins Protein evidence (Ezkurdia et al 2014) Show all		66 aa 7 kDa	No	0
RASGRP2-012 ENSP00000377949 ENST00000394428	A8MVK8 [Direct mapping] RAS guanyl-releasing protein 2 Show all	Predicted intracellular proteins RAS pathway related proteins Protein evidence (Ezkurdia et al 2014) Show all		63 aa 6.5 kDa	No	0
RASGRP2-013 ENSP00000366705 ENST00000377485	A6NHE2 [Direct mapping] RAS guanyl-releasing protein 2 Show all	Predicted intracellular proteins RAS pathway related proteins Protein evidence (Ezkurdia et al 2014) Show all		97 aa 11.1 kDa	No	0
RASGRP2-014 ENSP00000389068 ENST00000419843	C9JKH6 [Direct mapping] RAS guanyl-releasing protein 2 Show all	Predicted intracellular proteins RAS pathway related proteins Protein evidence (Ezkurdia et al 2014) Show all		13 aa 1.3 kDa	No	0
RASGRP2-016 ENSP00000399114 ENST00000431822	E7EM78 [Direct mapping] RAS guanyl-releasing protein 2 Show all	Predicted intracellular proteins RAS pathway related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005085 [guanyl-nucleotide exchange factor activity] GO:0005622 [intracellular] GO:0007264 [small GTPase mediated signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	232 aa 27 kDa	No	0
RASGRP2-022 ENSP00000401314 ENST00000430645	C9JZ82 [Direct mapping] RAS guanyl-releasing protein 2 Show all	Predicted intracellular proteins RAS pathway related proteins Protein evidence (Ezkurdia et al 2014) Show all		84 aa 9.7 kDa	No	0

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The Human Protein Atlas

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