Fields »
ABOUT
HELP
BLOG
RASGRP2

GENERAL INFORMATION

Gene name

 RASGRP2

Gene description

 RAS guanyl releasing protein 2 (calcium and DAG-regulated)

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

 Intracellular

Number of transcripts

 14
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (lymph node, spleen)
GTEx:Expressed in all
FANTOM5:Tissue enhanced (caudate)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, Splice and/or transcript discrepancy exists.

Reliability score

 Approved based on 1 antibody.
HPA015667
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (lymph node, spleen)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (caudate)

GENE INFORMATION

Gene name

 RASGRP2 (HGNC Symbol)

Synonyms

 CALDAG-GEFI

Description

 RAS guanyl releasing protein 2 (calcium and DAG-regulated) (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a brain-enriched nucleotide exchanged factor that contains an N-terminal GEF domain, 2 tandem repeats of EF-hand calcium-binding motifs, and a C-terminal diacylglycerol/phorbol ester-binding domain. This protein can activate small GTPases, including RAS and RAP1/RAS3. The nucleotide exchange activity of this protein can be stimulated by calcium and diacylglycerol. Three alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 11

Cytoband

 q13.1

Chromosome location (bp)

 64726911 - 64745456

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000068831 (version 83.38)

Entrez gene

 10235

UniProt

 Q7LDG7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q7LDG7

Antibodypedia

 RASGRP2 antibodies

PROTEIN BROWSER
«
RASGRP2-001
RASGRP2-002
RASGRP2-003
RASGRP2-005
RASGRP2-007
RASGRP2-008
RASGRP2-009
RASGRP2-010
RASGRP2-011
RASGRP2-012
RASGRP2-013
RASGRP2-014
RASGRP2-016
RASGRP2-022
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RASGRP2-001
ENSP00000377953
ENST00000394432
Q7LDG7 [Direct mapping]
RAS guanyl-releasing protein 2
Show all
Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558 [regulation of cell growth]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005509 [calcium ion binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007596 [blood coagulation]
GO:0008289 [lipid binding]
GO:0019992 [diacylglycerol binding]
GO:0030054 [cell junction]
GO:0030168 [platelet activation]
GO:0032587 [ruffle membrane]
GO:0035556 [intracellular signal transduction]
GO:0043005 [neuron projection]
GO:0043547 [positive regulation of GTPase activity]
GO:0045202 [synapse]
GO:0071277 [cellular response to calcium ion]
Show all
 609 aa
69.2 kDa 		No 0
RASGRP2-002
ENSP00000338864
ENST00000354024
Q7LDG7 [Direct mapping]
RAS guanyl-releasing protein 2
Show all
Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558 [regulation of cell growth]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005509 [calcium ion binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007596 [blood coagulation]
GO:0008289 [lipid binding]
GO:0019992 [diacylglycerol binding]
GO:0030054 [cell junction]
GO:0030168 [platelet activation]
GO:0032587 [ruffle membrane]
GO:0035556 [intracellular signal transduction]
GO:0043005 [neuron projection]
GO:0043547 [positive regulation of GTPase activity]
GO:0045202 [synapse]
GO:0071277 [cellular response to calcium ion]
Show all
 609 aa
69.2 kDa 		No 0
RASGRP2-003
ENSP00000366717
ENST00000377497
Q7LDG7 [Direct mapping]
RAS guanyl-releasing protein 2
Show all
Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558 [regulation of cell growth]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005509 [calcium ion binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007596 [blood coagulation]
GO:0008289 [lipid binding]
GO:0019992 [diacylglycerol binding]
GO:0030054 [cell junction]
GO:0030168 [platelet activation]
GO:0032587 [ruffle membrane]
GO:0035556 [intracellular signal transduction]
GO:0043005 [neuron projection]
GO:0043547 [positive regulation of GTPase activity]
GO:0045202 [synapse]
GO:0071277 [cellular response to calcium ion]
Show all
 609 aa
69.2 kDa 		No 0
RASGRP2-005
ENSP00000377951
ENST00000394430
A6NJ28 [Direct mapping]
RAS guanyl-releasing protein 2
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 148 aa
16.6 kDa 		No 0
RASGRP2-007
ENSP00000366714
ENST00000377494
Q7LDG7 [Direct mapping]
RAS guanyl-releasing protein 2
Show all
Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558 [regulation of cell growth]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005509 [calcium ion binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007596 [blood coagulation]
GO:0008289 [lipid binding]
GO:0019992 [diacylglycerol binding]
GO:0030054 [cell junction]
GO:0030168 [platelet activation]
GO:0032587 [ruffle membrane]
GO:0035556 [intracellular signal transduction]
GO:0043005 [neuron projection]
GO:0043547 [positive regulation of GTPase activity]
GO:0045202 [synapse]
GO:0071277 [cellular response to calcium ion]
Show all
 610 aa
69.3 kDa 		No 0
RASGRP2-008
ENSP00000366709
ENST00000377489
A6NJ28 [Direct mapping]
RAS guanyl-releasing protein 2
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 148 aa
16.6 kDa 		No 0
RASGRP2-009
ENSP00000366707
ENST00000377487
A6NJ28 [Direct mapping]
RAS guanyl-releasing protein 2
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 148 aa
16.6 kDa 		No 0
RASGRP2-010
ENSP00000366706
ENST00000377486
A6NJ28 [Direct mapping]
RAS guanyl-releasing protein 2
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 148 aa
16.6 kDa 		No 0
RASGRP2-011
ENSP00000377950
ENST00000394429
A8MTF9 [Direct mapping]
RAS guanyl-releasing protein 2
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 66 aa
7 kDa 		No 0
RASGRP2-012
ENSP00000377949
ENST00000394428
A8MVK8 [Direct mapping]
RAS guanyl-releasing protein 2
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 63 aa
6.5 kDa 		No 0
RASGRP2-013
ENSP00000366705
ENST00000377485
A6NHE2 [Direct mapping]
RAS guanyl-releasing protein 2
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 97 aa
11.1 kDa 		No 0
RASGRP2-014
ENSP00000389068
ENST00000419843
C9JKH6 [Direct mapping]
RAS guanyl-releasing protein 2
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 13 aa
1.3 kDa 		No 0
RASGRP2-016
ENSP00000399114
ENST00000431822
E7EM78 [Direct mapping]
RAS guanyl-releasing protein 2
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005622 [intracellular]
GO:0007264 [small GTPase mediated signal transduction]
GO:0043547 [positive regulation of GTPase activity]
Show all
 232 aa
27 kDa 		No 0
RASGRP2-022
ENSP00000401314
ENST00000430645
C9JZ82 [Direct mapping]
RAS guanyl-releasing protein 2
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 84 aa
9.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.