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TRPC7

GENERAL INFORMATION

Gene name

 TRPC7

Gene description

 Transient receptor potential cation channel, subfamily C, member 7

Protein class

 Predicted membrane proteins
Voltage-gated ion channels

Predicted localization

 Membrane

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Not detected
HPA (cell line):Not detected
HPA (normal tissue):Not detected

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. No RNA expression data detected and pending external verification.

Reliability score

 Uncertain based on 2 antibodies.
HPA031126 , CAB022592
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Not detected

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA031126
CAB022592

GENE INFORMATION

Gene name

 TRPC7

Synonyms

Description

 Transient receptor potential cation channel, subfamily C, member 7 (HGNC Symbol)

Entrez gene summary

Chromosome

 5

Cytoband

 q31.1

Chromosome location (bp)

 136213320 - 136365537

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000069018 (version 83.38)

Entrez gene

 57113

UniProt

 Q9HCX4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9HCX4

Antibodypedia

 TRPC7 antibodies

PROTEIN BROWSER
TRPC7-001
TRPC7-003
TRPC7-005
TRPC7-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TRPC7-001
ENSP00000426070
ENST00000513104
Q9HCX4 [Direct mapping]
Short transient receptor potential channel 7
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Voltage-gated ion channels
   Transient Receptor Potential Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
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GO:0005216 [ion channel activity]
GO:0005262 [calcium channel activity]
GO:0005515 [protein binding]
GO:0005635 [nuclear envelope]
GO:0005801 [cis-Golgi network]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0006816 [calcium ion transport]
GO:0006828 [manganese ion transport]
GO:0007411 [axon guidance]
GO:0007596 [blood coagulation]
GO:0015279 [store-operated calcium channel activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030168 [platelet activation]
GO:0034220 [ion transmembrane transport]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051480 [cytosolic calcium ion homeostasis]
GO:0055085 [transmembrane transport]
GO:0070588 [calcium ion transmembrane transport]
GO:0070679 [inositol 1,4,5 trisphosphate binding]
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 862 aa
99.6 kDa 		No 7
TRPC7-003
ENSP00000330322
ENST00000352189
Q9HCX4 [Direct mapping]
Short transient receptor potential channel 7
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Voltage-gated ion channels
   Transient Receptor Potential Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Show all
GO:0005216 [ion channel activity]
GO:0005515 [protein binding]
GO:0005635 [nuclear envelope]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0006828 [manganese ion transport]
GO:0007411 [axon guidance]
GO:0007596 [blood coagulation]
GO:0015279 [store-operated calcium channel activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030168 [platelet activation]
GO:0034220 [ion transmembrane transport]
GO:0051480 [cytosolic calcium ion homeostasis]
GO:0055085 [transmembrane transport]
GO:0070588 [calcium ion transmembrane transport]
GO:0070679 [inositol 1,4,5 trisphosphate binding]
Show all
 746 aa
86.3 kDa 		No 6
TRPC7-005
ENSP00000367720
ENST00000378459
Q9HCX4 [Direct mapping]
Short transient receptor potential channel 7
Show all
Voltage-gated ion channels
   Transient Receptor Potential Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Show all
GO:0005216 [ion channel activity]
GO:0005515 [protein binding]
GO:0005635 [nuclear envelope]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0006828 [manganese ion transport]
GO:0007411 [axon guidance]
GO:0007596 [blood coagulation]
GO:0015279 [store-operated calcium channel activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030168 [platelet activation]
GO:0034220 [ion transmembrane transport]
GO:0051480 [cytosolic calcium ion homeostasis]
GO:0055085 [transmembrane transport]
GO:0070588 [calcium ion transmembrane transport]
GO:0070679 [inositol 1,4,5 trisphosphate binding]
Show all
 801 aa
92.4 kDa 		No 7
TRPC7-006
ENSP00000424854
ENST00000502753
Q70T25 [Direct mapping]
Short transient receptor potential channel 7; Transient receptor potential channel 7
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Show all
GO:0005216 [ion channel activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0006828 [manganese ion transport]
GO:0015279 [store-operated calcium channel activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0051480 [cytosolic calcium ion homeostasis]
GO:0055085 [transmembrane transport]
GO:0070588 [calcium ion transmembrane transport]
GO:0070679 [inositol 1,4,5 trisphosphate binding]
Show all
 807 aa
93.4 kDa 		No 6

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.