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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

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Score

Score

Score

Antibodies

Column

 
 
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GAL
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    TISSUE

  • CELL

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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

GAL

Gene description

Galanin/GMAP prepropeptide

Protein class

Disease related genes
Plasma proteins
Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enhanced (appendix, smooth muscle)
GTEx:Tissue enriched (pituitary gland)
FANTOM5:Tissue enriched (pituitary gland)

Protein evidence

Evidence at protein level

Protein expression

Selective cytoplasmic expression in subsets of cells in anterior pituitary gland as well as in peripheral ganglion cells.

DATA RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data.

Reliability score

Supported based on 1 antibody.
HPA049864
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Pituitary gland
N/A
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Pituitary gland

Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (appendix, smooth muscle)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (pituitary gland)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (pituitary gland)

GENE INFORMATION

Gene name

GAL (HGNC Symbol)

Synonyms

GAL-GMAP, GALN, GLNN, GMAP

Description

Galanin/GMAP prepropeptide (HGNC Symbol)

Entrez gene summary

This gene encodes a neuroendocrine peptide that is widely expressed in the central and peripheral nervous systems and also the gastrointestinal tract, pancreas, adrenal gland and urogenital tract. The encoded protein is a precursor that is proteolytically processed to generate two mature peptides: galanin and galanin message-associated peptide (GMAP). Galanin has diverse physiological functions including nociception, feeding and energy homeostasis, osmotic regulation and water balance. GMAP has been demonstrated to possess antifungal activity and hypothesized to be part of the innate immune system. [provided by RefSeq, Jul 2015]

Chromosome

11

Cytoband

q13.2

Chromosome location (bp)

68683779 - 68691175

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000069482 (version 83.38)

Entrez gene

51083

UniProt

P22466 (UniProt - Evidence at protein level)

neXtProt

NX_P22466

Antibodypedia

GAL antibodies

PROTEIN BROWSER

GAL-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GAL-001
ENSP00000265643
ENST00000265643
P22466 [Direct mapping]
Galanin peptides Galanin Galanin message-associated peptide
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   MEMSAT3 predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005179 [hormone activity]
GO:0005184 [neuropeptide hormone activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0006954 [inflammatory response]
GO:0007218 [neuropeptide signaling pathway]
GO:0007399 [nervous system development]
GO:0007631 [feeding behavior]
GO:0008285 [negative regulation of cell proliferation]
GO:0010737 [protein kinase A signaling]
GO:0019933 [cAMP-mediated signaling]
GO:0030073 [insulin secretion]
GO:0030141 [secretory granule]
GO:0031764 [type 1 galanin receptor binding]
GO:0031765 [type 2 galanin receptor binding]
GO:0031766 [type 3 galanin receptor binding]
GO:0031943 [regulation of glucocorticoid metabolic process]
GO:0032868 [response to insulin]
GO:0035902 [response to immobilization stress]
GO:0042493 [response to drug]
GO:0043025 [neuronal cell body]
GO:0043065 [positive regulation of apoptotic process]
GO:0043627 [response to estrogen]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0050672 [negative regulation of lymphocyte proliferation]
GO:0051464 [positive regulation of cortisol secretion]
GO:0051795 [positive regulation of catagen]
GO:1902608 [positive regulation of large conductance calcium-activated potassium channel activity]
GO:1902891 [negative regulation of root hair elongation]
Show all
123 aa
13.3 kDa
Yes 0

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