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PLA2G10

GENERAL INFORMATION

Gene name

 PLA2G10

Gene description

 Phospholipase A2, group X

Protein class

 Enzymes
Predicted secreted proteins
RAS pathway related proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (CAPAN-2)
HPA (normal tissue):Tissue enhanced (colon, rectum, stomach)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA041893
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable).
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA041893

GENE INFORMATION

Gene name

 PLA2G10 (HGNC Symbol)

Synonyms

 GXPLA2

Description

 Phospholipase A2, group X (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the phospholipase A2 family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This calcium-dependent enzyme hydrolyzes glycerophospholipids to produce free fatty acids and lysophospholipids. In one example, this enzyme catalyzes the release of arachidonic acid from cell membrane phospholipids, thus playing a role in the production of various inflammatory lipid mediators, such as prostaglandins. The encoded protein may promote the survival of breast cancer cells through its role in lipid metabolism. [provided by RefSeq, Nov 2015]

Chromosome

 16

Cytoband

 p13.12

Chromosome location (bp)

 14672545 - 14694669

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000069764 (version 83.38)

Entrez gene

 8399

UniProt

 O15496 (UniProt - Evidence at protein level)

neXtProt

 NX_O15496

Antibodypedia

 PLA2G10 antibodies

PROTEIN BROWSER
PLA2G10-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PLA2G10-001
ENSP00000393847
ENST00000438167
O15496 [Direct mapping]
Group 10 secretory phospholipase A2
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Enzymes
   ENZYME proteins
   Hydrolases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
RAS pathway related proteins
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GO:0004620 [phospholipase activity]
GO:0004623 [phospholipase A2 activity]
GO:0005509 [calcium ion binding]
GO:0005576 [extracellular region]
GO:0006644 [phospholipid metabolic process]
GO:0006654 [phosphatidic acid biosynthetic process]
GO:0007411 [axon guidance]
GO:0010744 [positive regulation of macrophage derived foam cell differentiation]
GO:0010884 [positive regulation of lipid storage]
GO:0016042 [lipid catabolic process]
GO:0019369 [arachidonic acid metabolic process]
GO:0032270 [positive regulation of cellular protein metabolic process]
GO:0032308 [positive regulation of prostaglandin secretion]
GO:0036148 [phosphatidylglycerol acyl-chain remodeling]
GO:0036149 [phosphatidylinositol acyl-chain remodeling]
GO:0036150 [phosphatidylserine acyl-chain remodeling]
GO:0036151 [phosphatidylcholine acyl-chain remodeling]
GO:0036152 [phosphatidylethanolamine acyl-chain remodeling]
GO:0042632 [cholesterol homeostasis]
GO:0043030 [regulation of macrophage activation]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0044281 [small molecule metabolic process]
GO:0046474 [glycerophospholipid biosynthetic process]
GO:0051977 [lysophospholipid transport]
GO:0090238 [positive regulation of arachidonic acid secretion]
GO:0090370 [negative regulation of cholesterol efflux]
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 165 aa
18.2 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.