Tissue expression of PLA2G10 - Summary - The Human Protein Atlas

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PLA2G10

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	PLA2G10
Gene description	Phospholipase A2, group X
Protein class	Enzymes Predicted secreted proteins RAS pathway related proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (colon, rectum, stomach)
GTEx:	Group enriched (colon, lung, pancreas, small intestine, stomach, testis, urinary bladder)

Protein evidence

Evidence at protein level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA041893
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

N/A

Caudate

N/A

N/A

Cerebellum

N/A

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

N/A

Bronchus

N/A

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

N/A

Skin

N/A

Skin

N/A

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (colon, rectum, stomach)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (colon, lung, pancreas, small intestine, stomach, testis, urinary bladder)

GENE INFORMATION
Gene name	PLA2G10 (HGNC Symbol)
Synonyms	GXPLA2
Description	Phospholipase A2, group X (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the phospholipase A2 family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This calcium-dependent enzyme hydrolyzes glycerophospholipids to produce free fatty acids and lysophospholipids. In one example, this enzyme catalyzes the release of arachidonic acid from cell membrane phospholipids, thus playing a role in the production of various inflammatory lipid mediators, such as prostaglandins. The encoded protein may promote the survival of breast cancer cells through its role in lipid metabolism. [provided by RefSeq, Nov 2015]
Chromosome	16
Cytoband	p13.12
Chromosome location (bp)	14672545 - 14694669
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000069764 (version 83.38)
Entrez gene	8399
UniProt	O15496 (UniProt - Evidence at protein level)
neXtProt	NX_O15496
Antibodypedia	PLA2G10 antibodies

PROTEIN BROWSER

PLA2G10-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PLA2G10-001 ENSP00000393847 ENST00000438167	O15496 [Direct mapping] Group 10 secretory phospholipase A2 Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins RAS pathway related proteins Show all	GO:0004620 [phospholipase activity] GO:0004623 [phospholipase A2 activity] GO:0005509 [calcium ion binding] GO:0005576 [extracellular region] GO:0006644 [phospholipid metabolic process] GO:0006654 [phosphatidic acid biosynthetic process] GO:0007411 [axon guidance] GO:0010744 [positive regulation of macrophage derived foam cell differentiation] GO:0010884 [positive regulation of lipid storage] GO:0016042 [lipid catabolic process] GO:0019369 [arachidonic acid metabolic process] GO:0032270 [positive regulation of cellular protein metabolic process] GO:0032308 [positive regulation of prostaglandin secretion] GO:0036148 [phosphatidylglycerol acyl-chain remodeling] GO:0036149 [phosphatidylinositol acyl-chain remodeling] GO:0036150 [phosphatidylserine acyl-chain remodeling] GO:0036151 [phosphatidylcholine acyl-chain remodeling] GO:0036152 [phosphatidylethanolamine acyl-chain remodeling] GO:0042632 [cholesterol homeostasis] GO:0043030 [regulation of macrophage activation] GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity] GO:0044281 [small molecule metabolic process] GO:0046474 [glycerophospholipid biosynthetic process] GO:0051977 [lysophospholipid transport] GO:0090238 [positive regulation of arachidonic acid secretion] GO:0090370 [negative regulation of cholesterol efflux] Show all	165 aa 18.2 kDa	Yes	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.