Cell atlas - MAPK6 - The Human Protein Atlas

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MAPK6

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol

Human cell
	Cytosol

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GENERAL INFORMATION
Gene name	MAPK6
Gene description	Mitogen-activated protein kinase 6
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (validated)

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. CAB005184 , HPA030262
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol.

Main location

Cytosol (validated)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA030262	A-431	Cytosol
	HPA030262	U-2 OS	Cytosol
	HPA030262	U-251 MG	Cytosol
	CAB005184	A-431	No staining
	CAB005184	U-251 MG	Cytosol

GENE INFORMATION
Gene name	MAPK6 (HGNC Symbol)
Synonyms	ERK3, HsT17250, p97MAPK, PRKM6
Description	Mitogen-activated protein kinase 6 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the Ser/Thr protein kinase family, and is most closely related to mitogen-activated protein kinases (MAP kinases). MAP kinases also known as extracellular signal-regulated kinases (ERKs), are activated through protein phosphorylation cascades and act as integration points for multiple biochemical signals. This kinase is localized in the nucleus, and has been reported to be activated in fibroblasts upon treatment with serum or phorbol esters. [provided by RefSeq, Jul 2008]
Chromosome	15
Cytoband	q21.2
Chromosome location (bp)	51952106 - 52067372
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000069956 (version 83.38)
Entrez gene	5597
UniProt	Q16659 (UniProt - Evidence at protein level)
neXtProt	NX_Q16659
Antibodypedia	MAPK6 antibodies

PROTEIN BROWSER

MAPK6-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MAPK6-001 ENSP00000261845 ENST00000261845	Q16659 [Direct mapping] Mitogen-activated protein kinase 6 Show all	Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000165 [MAPK cascade] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004707 [MAP kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006468 [protein phosphorylation] GO:0007049 [cell cycle] GO:0007165 [signal transduction] GO:0019901 [protein kinase binding] GO:0046982 [protein heterodimerization activity] Show all	721 aa 82.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.