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MAPK6

GENERAL INFORMATION

Gene name

 MAPK6

Gene description

 Mitogen-activated protein kinase 6

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA030262 , CAB005184
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Endometrial cancer

STAINING SUMMARY
HPA030262
CAB005184

GENE INFORMATION

Gene name

 MAPK6 (HGNC Symbol)

Synonyms

 ERK3, HsT17250, p97MAPK, PRKM6

Description

 Mitogen-activated protein kinase 6 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the Ser/Thr protein kinase family, and is most closely related to mitogen-activated protein kinases (MAP kinases). MAP kinases also known as extracellular signal-regulated kinases (ERKs), are activated through protein phosphorylation cascades and act as integration points for multiple biochemical signals. This kinase is localized in the nucleus, and has been reported to be activated in fibroblasts upon treatment with serum or phorbol esters. [provided by RefSeq, Jul 2008]

Chromosome

 15

Cytoband

 q21.2

Chromosome location (bp)

 51952106 - 52067372

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000069956 (version 83.38)

Entrez gene

 5597

UniProt

 Q16659 (UniProt - Evidence at protein level)

neXtProt

 NX_Q16659

Antibodypedia

 MAPK6 antibodies

PROTEIN BROWSER
MAPK6-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MAPK6-001
ENSP00000261845
ENST00000261845
Q16659 [Direct mapping]
Mitogen-activated protein kinase 6
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000165 [MAPK cascade]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004707 [MAP kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0007049 [cell cycle]
GO:0007165 [signal transduction]
GO:0019901 [protein kinase binding]
GO:0046982 [protein heterodimerization activity]
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 721 aa
82.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.