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Cell lines sorted after organ of phenotypic resemblance.
Cell lines sorted after biological source for establishment.
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GENE INFORMATION
Gene name
PTPN3 (HGNC Symbol)
Synonyms
PTPH1
Description
Protein tyrosine phosphatase, non-receptor type 3 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. P97, a cell cycle regulator involved in a variety of membrane related functions, has been shown to be a substrate of this PTP. This PTP was also found to interact with, and be regulated by adaptor protein 14-3-3 beta. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]
P26045 [Direct mapping] Tyrosine-protein phosphatase non-receptor type 3
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Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001784 [phosphotyrosine binding] GO:0004725 [protein tyrosine phosphatase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0006470 [protein dephosphorylation] GO:0008092 [cytoskeletal protein binding] GO:0009898 [cytoplasmic side of plasma membrane] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0017080 [sodium channel regulator activity] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0045930 [negative regulation of mitotic cell cycle] GO:0051045 [negative regulation of membrane protein ectodomain proteolysis] GO:0051117 [ATPase binding] GO:0097421 [liver regeneration] GO:0098902 [regulation of membrane depolarization during action potential] GO:2000649 [regulation of sodium ion transmembrane transporter activity]
P26045 [Direct mapping] Tyrosine-protein phosphatase non-receptor type 3
Show all
Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001784 [phosphotyrosine binding] GO:0004725 [protein tyrosine phosphatase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0006470 [protein dephosphorylation] GO:0008092 [cytoskeletal protein binding] GO:0009898 [cytoplasmic side of plasma membrane] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0017080 [sodium channel regulator activity] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0045930 [negative regulation of mitotic cell cycle] GO:0051045 [negative regulation of membrane protein ectodomain proteolysis] GO:0051117 [ATPase binding] GO:0098902 [regulation of membrane depolarization during action potential] GO:2000649 [regulation of sodium ion transmembrane transporter activity]
P26045 [Direct mapping] Tyrosine-protein phosphatase non-receptor type 3
Show all
Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001784 [phosphotyrosine binding] GO:0004725 [protein tyrosine phosphatase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0006470 [protein dephosphorylation] GO:0008092 [cytoskeletal protein binding] GO:0009898 [cytoplasmic side of plasma membrane] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0017080 [sodium channel regulator activity] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0045930 [negative regulation of mitotic cell cycle] GO:0051045 [negative regulation of membrane protein ectodomain proteolysis] GO:0051117 [ATPase binding] GO:0098902 [regulation of membrane depolarization during action potential] GO:2000649 [regulation of sodium ion transmembrane transporter activity]
