Fields »
ABOUT
HELP
BLOG
PTPN3

GENERAL INFORMATION

Gene name

 PTPN3

Gene description

 Protein tyrosine phosphatase, non-receptor type 3

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Mixed
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and membranous expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA038343 , HPA046728
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable), endometrial cancer (favourable) and breast cancer (unfavourable).
Renal cancer p<0.001
Endometrial cancer p<0.001
Breast cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA038343
HPA046728

GENE INFORMATION

Gene name

 PTPN3 (HGNC Symbol)

Synonyms

 PTPH1

Description

 Protein tyrosine phosphatase, non-receptor type 3 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. P97, a cell cycle regulator involved in a variety of membrane related functions, has been shown to be a substrate of this PTP. This PTP was also found to interact with, and be regulated by adaptor protein 14-3-3 beta. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]

Chromosome

 9

Cytoband

 q31.3

Chromosome location (bp)

 109375466 - 109498313

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000070159 (version 83.38)

Entrez gene

 5774

UniProt

 P26045 (UniProt - Evidence at protein level)

neXtProt

 NX_P26045

Antibodypedia

 PTPN3 antibodies

PROTEIN BROWSER
PTPN3-001
PTPN3-201
PTPN3-202
PTPN3-203

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PTPN3-001
ENSP00000363667
ENST00000374541
P26045 [Direct mapping]
Tyrosine-protein phosphatase non-receptor type 3
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001784 [phosphotyrosine binding]
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0006470 [protein dephosphorylation]
GO:0008092 [cytoskeletal protein binding]
GO:0009898 [cytoplasmic side of plasma membrane]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0017080 [sodium channel regulator activity]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0045930 [negative regulation of mitotic cell cycle]
GO:0051045 [negative regulation of membrane protein ectodomain proteolysis]
GO:0051117 [ATPase binding]
GO:0097421 [liver regeneration]
GO:0098902 [regulation of membrane depolarization during action potential]
GO:2000649 [regulation of sodium ion transmembrane transporter activity]
Show all
 913 aa
104 kDa 		No 0
PTPN3-201
ENSP00000262539
ENST00000262539
J3KN34 [Direct mapping]
Tyrosine-protein phosphatase non-receptor type
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0006470 [protein dephosphorylation]
GO:0008092 [cytoskeletal protein binding]
GO:0019898 [extrinsic component of membrane]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
Show all
 839 aa
95.3 kDa 		No 0
PTPN3-202
ENSP00000416654
ENST00000412145
P26045 [Direct mapping]
Tyrosine-protein phosphatase non-receptor type 3
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001784 [phosphotyrosine binding]
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0006470 [protein dephosphorylation]
GO:0008092 [cytoskeletal protein binding]
GO:0009898 [cytoplasmic side of plasma membrane]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0017080 [sodium channel regulator activity]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0045930 [negative regulation of mitotic cell cycle]
GO:0051045 [negative regulation of membrane protein ectodomain proteolysis]
GO:0051117 [ATPase binding]
GO:0098902 [regulation of membrane depolarization during action potential]
GO:2000649 [regulation of sodium ion transmembrane transporter activity]
Show all
 782 aa
88.8 kDa 		No 0
PTPN3-203
ENSP00000395384
ENST00000446349
P26045 [Direct mapping]
Tyrosine-protein phosphatase non-receptor type 3
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001784 [phosphotyrosine binding]
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0006470 [protein dephosphorylation]
GO:0008092 [cytoskeletal protein binding]
GO:0009898 [cytoplasmic side of plasma membrane]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0017080 [sodium channel regulator activity]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0045930 [negative regulation of mitotic cell cycle]
GO:0051045 [negative regulation of membrane protein ectodomain proteolysis]
GO:0051117 [ATPase binding]
GO:0098902 [regulation of membrane depolarization during action potential]
GO:2000649 [regulation of sodium ion transmembrane transporter activity]
Show all
 737 aa
83.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.