Cell atlas - POLB - The Human Protein Atlas

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POLB

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TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS MOUSE CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Vesicles

Human cell
	Vesicles

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GENERAL INFORMATION
Gene name	POLB
Gene description	Polymerase (DNA directed), beta
Protein class	Enzymes FDA approved drug targets Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to vesicles.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (approved)
Mouse	Localized to the Vesicles in mouse cells.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA049104
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to vesicles.

Main location

Vesicles (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA049104	A-431	Vesicles
	HPA049104	U-2 OS	Vesicles
	HPA049104	U-251 MG	No staining

MOUSE CELLS

Main location

Vesicles

Mouse gene

ENSMUSG00000031536 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA049104	NIH 3T3	Vesicles

GENE INFORMATION
Gene name	POLB
Synonyms
Description	Polymerase (DNA directed), beta (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a DNA polymerase involved in base excision and repair, also called gap-filling DNA synthesis. The encoded protein, acting as a monomer, is normally found in the cytoplasm, but it translocates to the nucleus upon DNA damage. Several transcript variants of this gene exist, but the full-length nature of only one has been described to date. [provided by RefSeq, Sep 2011]
Chromosome	8
Cytoband	p11.21
Chromosome location (bp)	42338454 - 42371808
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000070501 (version 83.38)
Entrez gene	5423
UniProt	P06746 (UniProt - Evidence at protein level)
neXtProt	NX_P06746
Antibodypedia	POLB antibodies

PROTEIN BROWSER

POLB-001	POLB-002	POLB-005	POLB-006	POLB-008	POLB-011	POLB-012	POLB-016

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
POLB-001 ENSP00000265421 ENST00000265421	P06746 [Direct mapping] DNA polymerase beta Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Plasma proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003684 [damaged DNA binding] GO:0003887 [DNA-directed DNA polymerase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005874 [microtubule] GO:0005876 [spindle microtubule] GO:0006261 [DNA-dependent DNA replication] GO:0006281 [DNA repair] GO:0006284 [base-excision repair] GO:0006287 [base-excision repair, gap-filling] GO:0006290 [pyrimidine dimer repair] GO:0006915 [apoptotic process] GO:0006954 [inflammatory response] GO:0006974 [cellular response to DNA damage stimulus] GO:0007435 [salivary gland morphogenesis] GO:0007568 [aging] GO:0008017 [microtubule binding] GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] GO:0010332 [response to gamma radiation] GO:0016445 [somatic diversification of immunoglobulins] GO:0016446 [somatic hypermutation of immunoglobulin genes] GO:0016779 [nucleotidyltransferase activity] GO:0016829 [lyase activity] GO:0019899 [enzyme binding] GO:0034061 [DNA polymerase activity] GO:0043234 [protein complex] GO:0045471 [response to ethanol] GO:0046872 [metal ion binding] GO:0048535 [lymph node development] GO:0048536 [spleen development] GO:0048872 [homeostasis of number of cells] GO:0051402 [neuron apoptotic process] GO:0055093 [response to hyperoxia] GO:0071707 [immunoglobulin heavy chain V-D-J recombination] GO:0071897 [DNA biosynthetic process] Show all	335 aa 38.2 kDa	No	0
POLB-002 ENSP00000430610 ENST00000520008	E5RJ55 [Direct mapping] DNA polymerase beta Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0016779 [nucleotidyltransferase activity] GO:0034061 [DNA polymerase activity] GO:0071897 [DNA biosynthetic process] Show all	51 aa 5.6 kDa	No	0
POLB-005 ENSP00000430784 ENST00000518925	E7EW18 [Direct mapping] DNA polymerase beta Show all	MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003887 [DNA-directed DNA polymerase activity] GO:0006281 [DNA repair] GO:0016779 [nucleotidyltransferase activity] GO:0071897 [DNA biosynthetic process] Show all	280 aa 31.3 kDa	No	0
POLB-006 ENSP00000432084 ENST00000532157	E9PIC6 [Direct mapping] DNA polymerase beta Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0034061 [DNA polymerase activity] GO:0071897 [DNA biosynthetic process] Show all	38 aa 4.6 kDa	No	0
POLB-008 ENSP00000429597 ENST00000521290	H0YBJ0 [Direct mapping] DNA polymerase beta Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003887 [DNA-directed DNA polymerase activity] GO:0005634 [nucleus] GO:0006281 [DNA repair] GO:0016779 [nucleotidyltransferase activity] GO:0034061 [DNA polymerase activity] GO:0071897 [DNA biosynthetic process] Show all	237 aa 27.2 kDa	No	0
POLB-011 ENSP00000428144 ENST00000517393	H0YAV8 [Direct mapping] DNA polymerase beta Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		106 aa 11.7 kDa	No	0
POLB-012 ENSP00000430831 ENST00000521492	E5RHZ4 [Direct mapping] DNA polymerase beta Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		54 aa 6.3 kDa	No	0
POLB-016 ENSP00000430478 ENST00000518579	H0YBX1 [Direct mapping] DNA polymerase beta Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003887 [DNA-directed DNA polymerase activity] GO:0006281 [DNA repair] GO:0016779 [nucleotidyltransferase activity] GO:0034061 [DNA polymerase activity] GO:0071897 [DNA biosynthetic process] Show all	239 aa 27 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.