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Most cancer tissues showed weak to moderate nuclear positivity with additional cytoplasmic/membranous staining in few tissues. Several breast and few prostate cancers displayed strong immunoreactivity. Gliomas, lymphomas, renal cell carcinomas, several stomach and colorectal cancers were negative.
Tumour cells displayed weak to moderate nuclear immunoreactivity. Most breast and prostate cancers along with several melanomas, skin and pancreatic cancers were strongly stained. Renal cancers and a few lymphomas were negative.
GENE INFORMATION
Gene name
POLB
Synonyms
Description
Polymerase (DNA directed), beta (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a DNA polymerase involved in base excision and repair, also called gap-filling DNA synthesis. The encoded protein, acting as a monomer, is normally found in the cytoplasm, but it translocates to the nucleus upon DNA damage. Several transcript variants of this gene exist, but the full-length nature of only one has been described to date. [provided by RefSeq, Sep 2011]
Enzymes ENZYME proteins Transferases Predicted intracellular proteins Plasma proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)