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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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WIPI1
  • premium

    TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

WIPI1

Gene description

WD repeat domain, phosphoinositide interacting 1

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Supported based on 2 antibodies.
HPA007493 , CAB037230
SHOW MORE

PROGNOSTIC SUMMARY

Prognostic marker in melanoma (favourable).
Melanoma p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Melanoma

STAINING SUMMARY

HPA007493
CAB037230

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Melanomas displayed moderate to strong positivity while most breast, endometrial and prostate cancers were moderately stained. Cancer cells in general displayed weak cytoplasmic staining.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Cancer cells displayed moderate to strong cytoplasmic positivity. Additional nuclear staining was observed in several skin and thyroid cancers.

GENE INFORMATION

Gene name

WIPI1 (HGNC Symbol)

Synonyms

Atg18, ATG18A, FLJ10055, WIPI49

Description

WD repeat domain, phosphoinositide interacting 1 (HGNC Symbol)

Entrez gene summary

WD40 repeat proteins are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. Members of the WIPI subfamily of WD40 repeat proteins, such as WIPI1, have a 7-bladed propeller structure and contain a conserved motif for interaction with phospholipids (Proikas-Cezanne et al., 2004 [PubMed 15602573]).[supplied by OMIM, Mar 2008]

Chromosome

17

Cytoband

q24.2

Chromosome location (bp)

68420948 - 68457513

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000070540 (version 83.38)

Entrez gene

55062

UniProt

Q5MNZ9 (UniProt - Evidence at protein level)

neXtProt

NX_Q5MNZ9

Antibodypedia

WIPI1 antibodies

PROTEIN BROWSER

WIPI1-002
WIPI1-004
WIPI1-010
WIPI1-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

WIPI1-002
ENSP00000262139
ENST00000262139
Q5MNZ9 [Direct mapping]
WD repeat domain phosphoinositide-interacting protein 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000139 [Golgi membrane]
GO:0000407 [pre-autophagosomal structure]
GO:0000421 [autophagosome membrane]
GO:0000422 [mitophagy]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005802 [trans-Golgi network]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0006497 [protein lipidation]
GO:0006914 [autophagy]
GO:0006995 [cellular response to nitrogen starvation]
GO:0010008 [endosome membrane]
GO:0016236 [macroautophagy]
GO:0019898 [extrinsic component of membrane]
GO:0030136 [clathrin-coated vesicle]
GO:0030331 [estrogen receptor binding]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0032266 [phosphatidylinositol-3-phosphate binding]
GO:0034045 [pre-autophagosomal structure membrane]
GO:0034497 [protein localization to pre-autophagosomal structure]
GO:0036498 [IRE1-mediated unfolded protein response]
GO:0044267 [cellular protein metabolic process]
GO:0044804 [nucleophagy]
GO:0048203 [vesicle targeting, trans-Golgi to endosome]
GO:0050681 [androgen receptor binding]
GO:0080025 [phosphatidylinositol-3,5-bisphosphate binding]
Show all
446 aa
48.7 kDa
No 0
WIPI1-004
ENSP00000437345
ENST00000546360
G5EA37 [Direct mapping]
WD repeat domain phosphoinositide-interacting protein 1; WD repeat domain, phosphoinositide interacting 1, isoform CRA_a
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000422 [mitophagy]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006497 [protein lipidation]
GO:0006995 [cellular response to nitrogen starvation]
GO:0019898 [extrinsic component of membrane]
GO:0034497 [protein localization to pre-autophagosomal structure]
GO:0044804 [nucleophagy]
Show all
364 aa
39.9 kDa
No 0
WIPI1-010
ENSP00000466270
ENST00000591744
K7ELY0 [Direct mapping]
WD repeat domain phosphoinositide-interacting protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000422 [mitophagy]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006497 [protein lipidation]
GO:0006995 [cellular response to nitrogen starvation]
GO:0019898 [extrinsic component of membrane]
GO:0034497 [protein localization to pre-autophagosomal structure]
GO:0044804 [nucleophagy]
Show all
205 aa
22.3 kDa
No 0
WIPI1-011
ENSP00000465557
ENST00000585393
K7EKC5 [Direct mapping]
WD repeat domain phosphoinositide-interacting protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000422 [mitophagy]
GO:0005829 [cytosol]
GO:0006497 [protein lipidation]
GO:0006995 [cellular response to nitrogen starvation]
GO:0019898 [extrinsic component of membrane]
GO:0034497 [protein localization to pre-autophagosomal structure]
GO:0044804 [nucleophagy]
Show all
54 aa
5.5 kDa
No 0

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