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WIPI1

GENERAL INFORMATION

Gene name

 WIPI1

Gene description

 WD repeat domain, phosphoinositide interacting 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA007493 , CAB037230
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 WIPI1 (HGNC Symbol)

Synonyms

 Atg18, ATG18A, FLJ10055, WIPI49

Description

 WD repeat domain, phosphoinositide interacting 1 (HGNC Symbol)

Entrez gene summary

 WD40 repeat proteins are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. Members of the WIPI subfamily of WD40 repeat proteins, such as WIPI1, have a 7-bladed propeller structure and contain a conserved motif for interaction with phospholipids (Proikas-Cezanne et al., 2004 [PubMed 15602573]).[supplied by OMIM, Mar 2008]

Chromosome

 17

Cytoband

 q24.2

Chromosome location (bp)

 68420948 - 68457513

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000070540 (version 83.38)

Entrez gene

 55062

UniProt

 Q5MNZ9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q5MNZ9

Antibodypedia

 WIPI1 antibodies

PROTEIN BROWSER
WIPI1-002
WIPI1-004
WIPI1-010
WIPI1-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
WIPI1-002
ENSP00000262139
ENST00000262139
Q5MNZ9 [Direct mapping]
WD repeat domain phosphoinositide-interacting protein 1
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000139 [Golgi membrane]
GO:0000407 [pre-autophagosomal structure]
GO:0000421 [autophagosome membrane]
GO:0000422 [mitophagy]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005802 [trans-Golgi network]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0006497 [protein lipidation]
GO:0006914 [autophagy]
GO:0006995 [cellular response to nitrogen starvation]
GO:0010008 [endosome membrane]
GO:0016236 [macroautophagy]
GO:0019898 [extrinsic component of membrane]
GO:0030136 [clathrin-coated vesicle]
GO:0030331 [estrogen receptor binding]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0032266 [phosphatidylinositol-3-phosphate binding]
GO:0034045 [pre-autophagosomal structure membrane]
GO:0034497 [protein localization to pre-autophagosomal structure]
GO:0036498 [IRE1-mediated unfolded protein response]
GO:0044267 [cellular protein metabolic process]
GO:0044804 [nucleophagy]
GO:0048203 [vesicle targeting, trans-Golgi to endosome]
GO:0050681 [androgen receptor binding]
GO:0080025 [phosphatidylinositol-3,5-bisphosphate binding]
Show all
 446 aa
48.7 kDa 		No 0
WIPI1-004
ENSP00000437345
ENST00000546360
G5EA37 [Direct mapping]
WD repeat domain phosphoinositide-interacting protein 1; WD repeat domain, phosphoinositide interacting 1, isoform CRA_a
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000422 [mitophagy]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006497 [protein lipidation]
GO:0006995 [cellular response to nitrogen starvation]
GO:0019898 [extrinsic component of membrane]
GO:0034497 [protein localization to pre-autophagosomal structure]
GO:0044804 [nucleophagy]
Show all
 364 aa
39.9 kDa 		No 0
WIPI1-010
ENSP00000466270
ENST00000591744
K7ELY0 [Direct mapping]
WD repeat domain phosphoinositide-interacting protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000422 [mitophagy]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006497 [protein lipidation]
GO:0006995 [cellular response to nitrogen starvation]
GO:0019898 [extrinsic component of membrane]
GO:0034497 [protein localization to pre-autophagosomal structure]
GO:0044804 [nucleophagy]
Show all
 205 aa
22.3 kDa 		No 0
WIPI1-011
ENSP00000465557
ENST00000585393
K7EKC5 [Direct mapping]
WD repeat domain phosphoinositide-interacting protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000422 [mitophagy]
GO:0005829 [cytosol]
GO:0006497 [protein lipidation]
GO:0006995 [cellular response to nitrogen starvation]
GO:0019898 [extrinsic component of membrane]
GO:0034497 [protein localization to pre-autophagosomal structure]
GO:0044804 [nucleophagy]
Show all
 54 aa
5.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.