Cell atlas - NDST1 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

NDST1

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	NDST1
Gene description	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	5
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	NDST1 (HGNC Symbol)
Synonyms	HSST, NST1
Description	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family. The encoded enzyme is a type II transmembrane protein that resides in the Golgi apparatus. The encoded protein catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate to nitrogen of glucosamine in heparan sulfate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Chromosome	5
Cytoband	q33.1
Chromosome location (bp)	150485818 - 150558211
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000070614 (version 83.38)
Entrez gene	3340
UniProt	P52848 (UniProt - Evidence at protein level)
neXtProt	NX_P52848
Antibodypedia	NDST1 antibodies

PROTEIN BROWSER

NDST1-001	NDST1-002	NDST1-004	NDST1-007	NDST1-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NDST1-001 ENSP00000428604 ENST00000523767	E7EVJ3 [Direct mapping] Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0008146 [sulfotransferase activity] GO:0008152 [metabolic process] GO:0015016 [[heparan sulfate]-glucosamine N-sulfotransferase activity] GO:0016021 [integral component of membrane] GO:0016787 [hydrolase activity] Show all	825 aa 94.4 kDa	No	1
NDST1-002 ENSP00000261797 ENST00000261797	P52848 [Direct mapping] Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 Heparan sulfate N-deacetylase 1 Heparan sulfate N-sulfotransferase 1 Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0000165 [MAPK cascade] GO:0000271 [polysaccharide biosynthetic process] GO:0003279 [cardiac septum development] GO:0005975 [carbohydrate metabolic process] GO:0006024 [glycosaminoglycan biosynthetic process] GO:0006954 [inflammatory response] GO:0007224 [smoothened signaling pathway] GO:0007507 [heart development] GO:0007585 [respiratory gaseous exchange] GO:0008146 [sulfotransferase activity] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0009887 [organ morphogenesis] GO:0015012 [heparan sulfate proteoglycan biosynthetic process] GO:0015016 [[heparan sulfate]-glucosamine N-sulfotransferase activity] GO:0016021 [integral component of membrane] GO:0016787 [hydrolase activity] GO:0019213 [deacetylase activity] GO:0030203 [glycosaminoglycan metabolic process] GO:0030210 [heparin biosynthetic process] GO:0030900 [forebrain development] GO:0030901 [midbrain development] GO:0035904 [aorta development] GO:0044281 [small molecule metabolic process] GO:0048702 [embryonic neurocranium morphogenesis] GO:0048703 [embryonic viscerocranium morphogenesis] GO:0060976 [coronary vasculature development] Show all	882 aa 100.9 kDa	No	1
NDST1-004 ENSP00000430258 ENST00000518299	E5RG24 [Direct mapping] Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		23 aa 2.6 kDa	No	0
NDST1-007 ENSP00000429966 ENST00000522491	E5RGN9 [Direct mapping] Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	68 aa 7.6 kDa	No	0
NDST1-008 ENSP00000427813 ENST00000519157	E5RG58 [Direct mapping] Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0015016 [[heparan sulfate]-glucosamine N-sulfotransferase activity] GO:0016021 [integral component of membrane] GO:0016787 [hydrolase activity] Show all	159 aa 17.9 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.