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Carcinoids, hepatocellular carcinomas, prostate and head and neck cancers showed moderate to strong cytoplasmic staining. Membranous immunoreactivity was displayed in several cases of squamous cell carcinomas of lung and skin and urothelial cancers. Remaining cancer tissues were weakly stained or negative.
This gene encodes a member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family. The encoded enzyme is a type II transmembrane protein that resides in the Golgi apparatus. The encoded protein catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate to nitrogen of glucosamine in heparan sulfate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]