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ASNS

GENERAL INFORMATION

Gene name

 ASNS

Gene description

 Asparagine synthetase (glutamine-hydrolyzing)

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 13
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several different tissue types.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA029318
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 ASNS

Synonyms

Description

 Asparagine synthetase (glutamine-hydrolyzing) (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is involved in the synthesis of asparagine. This gene complements a mutation in the temperature-sensitive hamster mutant ts11, which blocks progression through the G1 phase of the cell cycle at nonpermissive temperature. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010]

Chromosome

 7

Cytoband

 q21.3

Chromosome location (bp)

 97852118 - 97872542

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000070669 (version 83.38)

Entrez gene

 440

UniProt

 P08243 (UniProt - Evidence at protein level)

neXtProt

 NX_P08243

Antibodypedia

 ASNS antibodies

PROTEIN BROWSER
«
ASNS-001
ASNS-002
ASNS-005
ASNS-006
ASNS-007
ASNS-008
ASNS-011
ASNS-014
ASNS-015
ASNS-016
ASNS-017
ASNS-021
ASNS-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ASNS-001
ENSP00000377845
ENST00000394308
P08243 [Direct mapping]
Asparagine synthetase [glutamine-hydrolyzing]
Show all
Enzymes
   ENZYME proteins
   Ligase
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004066 [asparagine synthase (glutamine-hydrolyzing) activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0006529 [asparagine biosynthetic process]
GO:0006541 [glutamine metabolic process]
GO:0008652 [cellular amino acid biosynthetic process]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0036499 [PERK-mediated unfolded protein response]
GO:0042149 [cellular response to glucose starvation]
GO:0042803 [protein homodimerization activity]
GO:0043066 [negative regulation of apoptotic process]
GO:0044267 [cellular protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045931 [positive regulation of mitotic cell cycle]
GO:0070981 [L-asparagine biosynthetic process]
Show all
 561 aa
64.4 kDa 		No 0
ASNS-002
ENSP00000414901
ENST00000422745
P08243 [Direct mapping]
Asparagine synthetase [glutamine-hydrolyzing]
Show all
Enzymes
   ENZYME proteins
   Ligase
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004066 [asparagine synthase (glutamine-hydrolyzing) activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0006529 [asparagine biosynthetic process]
GO:0006541 [glutamine metabolic process]
GO:0008652 [cellular amino acid biosynthetic process]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0036499 [PERK-mediated unfolded protein response]
GO:0042149 [cellular response to glucose starvation]
GO:0042803 [protein homodimerization activity]
GO:0043066 [negative regulation of apoptotic process]
GO:0044267 [cellular protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045931 [positive regulation of mitotic cell cycle]
GO:0070981 [L-asparagine biosynthetic process]
Show all
 540 aa
62.2 kDa 		No 0
ASNS-005
ENSP00000406994
ENST00000444334
P08243 [Direct mapping]
Asparagine synthetase [glutamine-hydrolyzing]
Show all
Enzymes
   ENZYME proteins
   Ligase
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004066 [asparagine synthase (glutamine-hydrolyzing) activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0006529 [asparagine biosynthetic process]
GO:0006541 [glutamine metabolic process]
GO:0008652 [cellular amino acid biosynthetic process]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0036499 [PERK-mediated unfolded protein response]
GO:0042149 [cellular response to glucose starvation]
GO:0042803 [protein homodimerization activity]
GO:0043066 [negative regulation of apoptotic process]
GO:0044267 [cellular protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045931 [positive regulation of mitotic cell cycle]
GO:0070981 [L-asparagine biosynthetic process]
Show all
 540 aa
62.2 kDa 		No 0
ASNS-006
ENSP00000408472
ENST00000455086
P08243 [Direct mapping]
Asparagine synthetase [glutamine-hydrolyzing]
Show all
Enzymes
   ENZYME proteins
   Ligase
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004066 [asparagine synthase (glutamine-hydrolyzing) activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0006529 [asparagine biosynthetic process]
GO:0006541 [glutamine metabolic process]
GO:0008652 [cellular amino acid biosynthetic process]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0036499 [PERK-mediated unfolded protein response]
GO:0042149 [cellular response to glucose starvation]
GO:0042803 [protein homodimerization activity]
GO:0043066 [negative regulation of apoptotic process]
GO:0044267 [cellular protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045931 [positive regulation of mitotic cell cycle]
GO:0070981 [L-asparagine biosynthetic process]
Show all
 478 aa
54.8 kDa 		No 0
ASNS-007
ENSP00000377846
ENST00000394309
P08243 [Direct mapping]
Asparagine synthetase [glutamine-hydrolyzing]
Show all
Enzymes
   ENZYME proteins
   Ligase
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004066 [asparagine synthase (glutamine-hydrolyzing) activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0006529 [asparagine biosynthetic process]
GO:0006541 [glutamine metabolic process]
GO:0008652 [cellular amino acid biosynthetic process]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0036499 [PERK-mediated unfolded protein response]
GO:0042149 [cellular response to glucose starvation]
GO:0042803 [protein homodimerization activity]
GO:0043066 [negative regulation of apoptotic process]
GO:0044267 [cellular protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045931 [positive regulation of mitotic cell cycle]
GO:0070981 [L-asparagine biosynthetic process]
Show all
 561 aa
64.4 kDa 		No 0
ASNS-008
ENSP00000414379
ENST00000437628
P08243 [Direct mapping]
Asparagine synthetase [glutamine-hydrolyzing]
Show all
Enzymes
   ENZYME proteins
   Ligase
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004066 [asparagine synthase (glutamine-hydrolyzing) activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0006529 [asparagine biosynthetic process]
GO:0006541 [glutamine metabolic process]
GO:0008652 [cellular amino acid biosynthetic process]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0036499 [PERK-mediated unfolded protein response]
GO:0042149 [cellular response to glucose starvation]
GO:0042803 [protein homodimerization activity]
GO:0043066 [negative regulation of apoptotic process]
GO:0044267 [cellular protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045931 [positive regulation of mitotic cell cycle]
GO:0070981 [L-asparagine biosynthetic process]
Show all
 478 aa
54.8 kDa 		No 0
ASNS-011
ENSP00000397802
ENST00000451771
C9J605 [Direct mapping]
Asparagine synthetase [glutamine-hydrolyzing]
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 33 aa
3.6 kDa 		No 0
ASNS-014
ENSP00000408797
ENST00000453600
C9JLN6 [Direct mapping]
Asparagine synthetase [glutamine-hydrolyzing]
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 63 aa
7.5 kDa 		No 0
ASNS-015
ENSP00000400422
ENST00000442734
C9J057 [Direct mapping]
Asparagine synthetase [glutamine-hydrolyzing]
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 215 aa
24.4 kDa 		No 0
ASNS-016
ENSP00000413797
ENST00000414884
C9JLA3 [Direct mapping]
Asparagine synthetase [glutamine-hydrolyzing]
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 28 aa
3 kDa 		No 0
ASNS-017
ENSP00000402350
ENST00000448127
C9JM09 [Direct mapping]
Asparagine synthetase [glutamine-hydrolyzing]
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 119 aa
13.8 kDa 		No 0
ASNS-021
ENSP00000394242
ENST00000437657
C9JT45 [Direct mapping]
Asparagine synthetase [glutamine-hydrolyzing]
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 162 aa
18.5 kDa 		No 0
ASNS-201
ENSP00000175506
ENST00000175506
P08243 [Direct mapping]
Asparagine synthetase [glutamine-hydrolyzing]
Show all
Enzymes
   ENZYME proteins
   Ligase
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001889 [liver development]
GO:0004066 [asparagine synthase (glutamine-hydrolyzing) activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0006520 [cellular amino acid metabolic process]
GO:0006529 [asparagine biosynthetic process]
GO:0006541 [glutamine metabolic process]
GO:0008652 [cellular amino acid biosynthetic process]
GO:0009416 [response to light stimulus]
GO:0009612 [response to mechanical stimulus]
GO:0009636 [response to toxic substance]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0031427 [response to methotrexate]
GO:0031667 [response to nutrient levels]
GO:0032354 [response to follicle-stimulating hormone]
GO:0032870 [cellular response to hormone stimulus]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0036499 [PERK-mediated unfolded protein response]
GO:0042149 [cellular response to glucose starvation]
GO:0042803 [protein homodimerization activity]
GO:0043066 [negative regulation of apoptotic process]
GO:0043200 [response to amino acid]
GO:0044267 [cellular protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045931 [positive regulation of mitotic cell cycle]
GO:0048037 [cofactor binding]
GO:0070981 [L-asparagine biosynthetic process]
Show all
 561 aa
64.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.