Expression of PABPC1 in cancer - Summary

GENERAL INFORMATION
Gene name	PABPC1
Gene description	Poly(A) binding protein, cytoplasmic 1
Protein class	Cancer-related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	18
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.
Reliability score	Supported based on 2 antibodies. HPA045423 , CAB011536
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), glioma (favourable) and liver cancer (unfavourable).
Renal cancer p<0.001 Glioma p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA045423	CAB011536

GENE INFORMATION
Gene name	PABPC1 (HGNC Symbol)
Synonyms	PAB1, PABP1, PABPC2, PABPL1
Description	Poly(A) binding protein, cytoplasmic 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a poly(A) binding protein. The protein shuttles between the nucleus and cytoplasm and binds to the 3' poly(A) tail of eukaryotic messenger RNAs via RNA-recognition motifs. The binding of this protein to poly(A) promotes ribosome recruitment and translation initiation; it is also required for poly(A) shortening which is the first step in mRNA decay. The gene is part of a small gene family including three protein-coding genes and several pseudogenes.[provided by RefSeq, Aug 2010]
Chromosome	8
Cytoband	q22.3
Chromosome location (bp)	100685816 - 100722809
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000070756 (version 83.38)
Entrez gene	26986
UniProt	P11940 (UniProt - Evidence at protein level)
neXtProt	NX_P11940
Antibodypedia	PABPC1 antibodies

PROTEIN BROWSER

PABPC1-001	PABPC1-002	PABPC1-003	PABPC1-005	PABPC1-006	PABPC1-007	PABPC1-008	PABPC1-009	PABPC1-012	PABPC1-015	PABPC1-016	PABPC1-017	PABPC1-018	PABPC1-019	PABPC1-020	PABPC1-021	PABPC1-025	PABPC1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PABPC1-001 ENSP00000313007 ENST00000318607	P11940 [Direct mapping] Polyadenylate-binding protein 1 A0A024R9C1 [Target identity:100%; Query identity:100%] Polyadenylate-binding protein Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay] GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay] GO:0000289 [nuclear-transcribed mRNA poly(A) tail shortening] GO:0000398 [mRNA splicing, via spliceosome] GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005925 [focal adhesion] GO:0006378 [mRNA polyadenylation] GO:0006412 [translation] GO:0006413 [translational initiation] GO:0008022 [protein C-terminus binding] GO:0008143 [poly(A) binding] GO:0008266 [poly(U) RNA binding] GO:0008494 [translation activator activity] GO:0010467 [gene expression] GO:0010494 [cytoplasmic stress granule] GO:0016020 [membrane] GO:0030529 [ribonucleoprotein complex] GO:0031047 [gene silencing by RNA] GO:0036464 [cytoplasmic ribonucleoprotein granule] GO:0043488 [regulation of mRNA stability] GO:0044267 [cellular protein metabolic process] GO:0044822 [poly(A) RNA binding] GO:0045727 [positive regulation of translation] GO:0048255 [mRNA stabilization] GO:0060213 [positive regulation of nuclear-transcribed mRNA poly(A) tail shortening] GO:0070062 [extracellular exosome] GO:0071013 [catalytic step 2 spliceosome] GO:1900153 [positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay] GO:2000623 [negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay] Show all	636 aa 70.7 kDa	No	0
PABPC1-002 ENSP00000429594 ENST00000519004	E7EQV3 [Direct mapping] Polyadenylate-binding protein Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0005737 [cytoplasm] Show all	591 aa 65.7 kDa	No	0
PABPC1-003 ENSP00000429395 ENST00000522387	E7ERJ7 [Direct mapping] Polyadenylate-binding protein Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0005737 [cytoplasm] Show all	604 aa 67.1 kDa	No	0
PABPC1-005 ENSP00000428840 ENST00000522658	H0YB75 [Direct mapping] Polyadenylate-binding protein 1 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] Show all	183 aa 19.5 kDa	No	0
PABPC1-006 ENSP00000428021 ENST00000520868	H0YAS6 [Direct mapping] Polyadenylate-binding protein 1 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] Show all	169 aa 17.8 kDa	No	0
PABPC1-007 ENSP00000428190 ENST00000517403	H0YAW6 [Direct mapping] Polyadenylate-binding protein 1 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all		187 aa 20.7 kDa	No	0
PABPC1-008 ENSP00000430012 ENST00000520142	E5RH24 [Direct mapping] Polyadenylate-binding protein 1 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] Show all	118 aa 13.3 kDa	No	0
PABPC1-009 ENSP00000429892 ENST00000523555	H0YBN4 [Direct mapping] Polyadenylate-binding protein 1 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] Show all	175 aa 19.7 kDa	No	0
PABPC1-012 ENSP00000427914 ENST00000519100	H0YAR2 [Direct mapping] Polyadenylate-binding protein 1 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] Show all	284 aa 32.1 kDa	No	0
PABPC1-015 ENSP00000429119 ENST00000521865	E5RJB9 [Direct mapping] Polyadenylate-binding protein 1 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] Show all	129 aa 14.5 kDa	No	0
PABPC1-016 ENSP00000428937 ENST00000521067	E5RFD8 [Direct mapping] Polyadenylate-binding protein 1 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] Show all	61 aa 6.9 kDa	No	0
PABPC1-017 ENSP00000429790 ENST00000522720	E5RHG7 [Direct mapping] Polyadenylate-binding protein 1 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] Show all	75 aa 8.4 kDa	No	0
PABPC1-018 ENSP00000428749 ENST00000520804	E5RGC4 [Direct mapping] Polyadenylate-binding protein 1 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] Show all	43 aa 4.7 kDa	No	0
PABPC1-019 ENSP00000429032 ENST00000519363	E5RJM8 [Direct mapping] Polyadenylate-binding protein 1 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] Show all	38 aa 4.1 kDa	No	0
PABPC1-020 ENSP00000430159 ENST00000518196	E5RGH3 [Direct mapping] Polyadenylate-binding protein 1 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] Show all	108 aa 12.2 kDa	No	0
PABPC1-021 ENSP00000430716 ENST00000518293	H0YC10 [Direct mapping] Polyadenylate-binding protein 1 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] Show all	42 aa 4.3 kDa	No	0
PABPC1-025 ENSP00000428030 ENST00000517990	H0YAS7 [Direct mapping] Polyadenylate-binding protein 1 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] Show all	136 aa 14.4 kDa	No	0
PABPC1-201 ENSP00000478108 ENST00000610907	A0A087WTT1 [Direct mapping] Polyadenylate-binding protein Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0005737 [cytoplasm] Show all	522 aa 58.5 kDa	No	0