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CAMK2A

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GENERAL INFORMATION

Gene name

 CAMK2A

Gene description

 Calcium/calmodulin-dependent protein kinase II alpha

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the plasma membrane & cell junctions. Caution: Based on antibodies targeting proteins from multiple genes.

RNA cell category

 Group enriched (SCLC-21H, U-87 MG, HaCaT)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Plasma membrane (supported), Cell Junctions (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA051785
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (SCLC-21H, U-87 MG, HaCaT)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the plasma membrane & cell junctions. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

 Plasma membrane (supported), Cell Junctions (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA051785 A-431 No staining    
HPA051785 U-2 OS Plasma membrane
HPA051785 U-251 MG Plasma membrane
Cell Junctions

GENE INFORMATION

Gene name

 CAMK2A (HGNC Symbol)

Synonyms

 CAMKA, CaMKIINalpha, KIAA0968

Description

 Calcium/calmodulin-dependent protein kinase II alpha (HGNC Symbol)

Entrez gene summary

 The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2008]

Chromosome

 5

Cytoband

 q32

Chromosome location (bp)

 150219491 - 150290291

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000070808 (version 83.38)

Entrez gene

 815

UniProt

 Q9UQM7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UQM7

Antibodypedia

 CAMK2A antibodies

PROTEIN BROWSER
CAMK2A-001
CAMK2A-002
CAMK2A-005
CAMK2A-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CAMK2A-001
ENSP00000261793
ENST00000348628
Q9UQM7 [Direct mapping]
Calcium/calmodulin-dependent protein kinase type II subunit alpha
Q7LDD5 [Target identity:100%; Query identity:100%]
Calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha, isoform CRA_a; Calmodulin-dependent protein kinase II alpha
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0002931 [response to ischemia]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0006816 [calcium ion transport]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010666 [positive regulation of cardiac muscle cell apoptotic process]
GO:0016301 [kinase activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030054 [cell junction]
GO:0030666 [endocytic vesicle membrane]
GO:0034605 [cellular response to heat]
GO:0035254 [glutamate receptor binding]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038166 [angiotensin-activated signaling pathway]
GO:0042734 [presynaptic membrane]
GO:0042803 [protein homodimerization activity]
GO:0045087 [innate immune response]
GO:0046777 [protein autophosphorylation]
GO:0046928 [regulation of neurotransmitter secretion]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048168 [regulation of neuronal synaptic plasticity]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051928 [positive regulation of calcium ion transport]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:1900034 [regulation of cellular response to heat]
GO:1902108 [regulation of mitochondrial membrane permeability involved in apoptotic process]
Show all
 478 aa
54.1 kDa 		No 1
CAMK2A-002
ENSP00000381412
ENST00000398376
Q9UQM7 [Direct mapping]
Calcium/calmodulin-dependent protein kinase type II subunit alpha
A8K161 [Target identity:100%; Query identity:100%]
Calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha, isoform CRA_b; cDNA FLJ75193, highly similar to Homo sapiens calcium/calmodulin-dependent protein kinase II alpha-B subunit mRNA
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0002931 [response to ischemia]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0006816 [calcium ion transport]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010666 [positive regulation of cardiac muscle cell apoptotic process]
GO:0016301 [kinase activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030054 [cell junction]
GO:0030666 [endocytic vesicle membrane]
GO:0034605 [cellular response to heat]
GO:0035254 [glutamate receptor binding]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038166 [angiotensin-activated signaling pathway]
GO:0042734 [presynaptic membrane]
GO:0042803 [protein homodimerization activity]
GO:0045087 [innate immune response]
GO:0046777 [protein autophosphorylation]
GO:0046928 [regulation of neurotransmitter secretion]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048168 [regulation of neuronal synaptic plasticity]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051928 [positive regulation of calcium ion transport]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0097481 [neuronal postsynaptic density]
GO:1900034 [regulation of cellular response to heat]
GO:1902108 [regulation of mitochondrial membrane permeability involved in apoptotic process]
Show all
 489 aa
55.3 kDa 		No 1
CAMK2A-005
ENSP00000426607
ENST00000510347
D6RFJ0 [Direct mapping]
Calcium/calmodulin-dependent protein kinase type II subunit alpha
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 91 aa
10.6 kDa 		No 0
CAMK2A-007
ENSP00000427580
ENST00000515758
D6RHX9 [Direct mapping]
Calcium/calmodulin-dependent protein kinase type II subunit alpha
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 24 aa
2.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.