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CAMK2A

GENERAL INFORMATION

Gene name

 CAMK2A

Gene description

 Calcium/calmodulin-dependent protein kinase II alpha

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (glioma)
HPA (cell line):Group enriched (HaCaT, SCLC-21H, U-87 MG)
HPA (normal tissue):Tissue enriched (cerebral cortex)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Selective expression in neuropil and neurons in CNS.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Supported based on 4 antibodies.
HPA051783 , HPA051785 , HPA053973 , CAB004330
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (glioma)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Glioma

STAINING SUMMARY
HPA051783
HPA051785
HPA053973
CAB004330

GENE INFORMATION

Gene name

 CAMK2A (HGNC Symbol)

Synonyms

 CAMKA, CaMKIINalpha, KIAA0968

Description

 Calcium/calmodulin-dependent protein kinase II alpha (HGNC Symbol)

Entrez gene summary

 The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2008]

Chromosome

 5

Cytoband

 q32

Chromosome location (bp)

 150219491 - 150290291

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000070808 (version 83.38)

Entrez gene

 815

UniProt

 Q9UQM7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UQM7

Antibodypedia

 CAMK2A antibodies

PROTEIN BROWSER
CAMK2A-001
CAMK2A-002
CAMK2A-005
CAMK2A-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CAMK2A-001
ENSP00000261793
ENST00000348628
Q9UQM7 [Direct mapping]
Calcium/calmodulin-dependent protein kinase type II subunit alpha
Q7LDD5 [Target identity:100%; Query identity:100%]
Calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha, isoform CRA_a; Calmodulin-dependent protein kinase II alpha
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0002931 [response to ischemia]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0006816 [calcium ion transport]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010666 [positive regulation of cardiac muscle cell apoptotic process]
GO:0016301 [kinase activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030054 [cell junction]
GO:0030666 [endocytic vesicle membrane]
GO:0034605 [cellular response to heat]
GO:0035254 [glutamate receptor binding]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038166 [angiotensin-activated signaling pathway]
GO:0042734 [presynaptic membrane]
GO:0042803 [protein homodimerization activity]
GO:0045087 [innate immune response]
GO:0046777 [protein autophosphorylation]
GO:0046928 [regulation of neurotransmitter secretion]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048168 [regulation of neuronal synaptic plasticity]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051928 [positive regulation of calcium ion transport]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:1900034 [regulation of cellular response to heat]
GO:1902108 [regulation of mitochondrial membrane permeability involved in apoptotic process]
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 478 aa
54.1 kDa 		No 1
CAMK2A-002
ENSP00000381412
ENST00000398376
Q9UQM7 [Direct mapping]
Calcium/calmodulin-dependent protein kinase type II subunit alpha
A8K161 [Target identity:100%; Query identity:100%]
Calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha, isoform CRA_b; cDNA FLJ75193, highly similar to Homo sapiens calcium/calmodulin-dependent protein kinase II alpha-B subunit mRNA
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0002931 [response to ischemia]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0006816 [calcium ion transport]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010666 [positive regulation of cardiac muscle cell apoptotic process]
GO:0016301 [kinase activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030054 [cell junction]
GO:0030666 [endocytic vesicle membrane]
GO:0034605 [cellular response to heat]
GO:0035254 [glutamate receptor binding]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038166 [angiotensin-activated signaling pathway]
GO:0042734 [presynaptic membrane]
GO:0042803 [protein homodimerization activity]
GO:0045087 [innate immune response]
GO:0046777 [protein autophosphorylation]
GO:0046928 [regulation of neurotransmitter secretion]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048168 [regulation of neuronal synaptic plasticity]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051928 [positive regulation of calcium ion transport]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0097481 [neuronal postsynaptic density]
GO:1900034 [regulation of cellular response to heat]
GO:1902108 [regulation of mitochondrial membrane permeability involved in apoptotic process]
Show all
 489 aa
55.3 kDa 		No 1
CAMK2A-005
ENSP00000426607
ENST00000510347
D6RFJ0 [Direct mapping]
Calcium/calmodulin-dependent protein kinase type II subunit alpha
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
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 91 aa
10.6 kDa 		No 0
CAMK2A-007
ENSP00000427580
ENST00000515758
D6RHX9 [Direct mapping]
Calcium/calmodulin-dependent protein kinase type II subunit alpha
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
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 24 aa
2.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.