Expression of OSBPL3 in cancer - Summary

GENERAL INFORMATION
Gene name	OSBPL3
Gene description	Oxysterol binding protein-like 3
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in renal glomeruli, respiratory epithelium, urinary bladder and placenta.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA000691
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (unfavourable).
Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA000691

GENE INFORMATION
Gene name	OSBPL3 (HGNC Symbol)
Synonyms	KIAA0704, ORP-3, ORP3, OSBP3
Description	Oxysterol binding protein-like 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. The encoded protein is involved in the regulation of cell adhesion and organization of the actin cytoskeleton. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Chromosome	7
Cytoband	p15.3
Chromosome location (bp)	24796539 - 24981634
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000070882 (version 83.38)
Entrez gene	26031
UniProt	Q9H4L5 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H4L5
Antibodypedia	OSBPL3 antibodies

PROTEIN BROWSER

OSBPL3-001	OSBPL3-002	OSBPL3-003	OSBPL3-006	OSBPL3-009	OSBPL3-010	OSBPL3-015

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
OSBPL3-001 ENSP00000315410 ENST00000313367	Q9H4L5 [Direct mapping] Oxysterol-binding protein-related protein 3 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006869 [lipid transport] GO:0015485 [cholesterol binding] GO:0016020 [membrane] GO:0031965 [nuclear membrane] GO:0097038 [perinuclear endoplasmic reticulum] Show all	887 aa 101.2 kDa	No	0
OSBPL3-002 ENSP00000379708 ENST00000396431	Q9H4L5 [Direct mapping] Oxysterol-binding protein-related protein 3 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006869 [lipid transport] GO:0015485 [cholesterol binding] GO:0016020 [membrane] GO:0031965 [nuclear membrane] GO:0097038 [perinuclear endoplasmic reticulum] Show all	856 aa 97.7 kDa	No	0
OSBPL3-003 ENSP00000379706 ENST00000396429	Q9H4L5 [Direct mapping] Oxysterol-binding protein-related protein 3 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006869 [lipid transport] GO:0015485 [cholesterol binding] GO:0016020 [membrane] GO:0031965 [nuclear membrane] GO:0097038 [perinuclear endoplasmic reticulum] Show all	851 aa 97.3 kDa	No	0
OSBPL3-006 ENSP00000386953 ENST00000409069	Q9H4L5 [Direct mapping] Oxysterol-binding protein-related protein 3 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006869 [lipid transport] GO:0015485 [cholesterol binding] GO:0016020 [membrane] GO:0031965 [nuclear membrane] GO:0097038 [perinuclear endoplasmic reticulum] Show all	820 aa 93.8 kDa	No	0
OSBPL3-009 ENSP00000407829 ENST00000415162	C9JZ19 [Direct mapping] Oxysterol-binding protein-related protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		112 aa 12.8 kDa	No	0
OSBPL3-010 ENSP00000403374 ENST00000441059	C9JEF2 [Direct mapping] Oxysterol-binding protein-related protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		89 aa 10.3 kDa	No	0
OSBPL3-015 ENSP00000411249 ENST00000415952	C9J8P4 [Direct mapping] Oxysterol-binding protein-related protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		61 aa 6.8 kDa	No	0