Tissue expression of OSBPL3 - Summary - The Human Protein Atlas

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OSBPL3

TISSUE

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CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	OSBPL3
Gene description	Oxysterol binding protein-like 3
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Mixed
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in renal glomeruli, respiratory epithelium, urinary bladder and placenta.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA000691
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

Urinary bladder

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Mixed
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	OSBPL3 (HGNC Symbol)
Synonyms	KIAA0704, ORP-3, ORP3, OSBP3
Description	Oxysterol binding protein-like 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. The encoded protein is involved in the regulation of cell adhesion and organization of the actin cytoskeleton. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Chromosome	7
Cytoband	p15.3
Chromosome location (bp)	24796539 - 24981634
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000070882 (version 83.38)
Entrez gene	26031
UniProt	Q9H4L5 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H4L5
Antibodypedia	OSBPL3 antibodies

PROTEIN BROWSER

OSBPL3-001	OSBPL3-002	OSBPL3-003	OSBPL3-006	OSBPL3-009	OSBPL3-010	OSBPL3-015

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
OSBPL3-001 ENSP00000315410 ENST00000313367	Q9H4L5 [Direct mapping] Oxysterol-binding protein-related protein 3 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006869 [lipid transport] GO:0015485 [cholesterol binding] GO:0016020 [membrane] GO:0031965 [nuclear membrane] GO:0097038 [perinuclear endoplasmic reticulum] Show all	887 aa 101.2 kDa	No	0
OSBPL3-002 ENSP00000379708 ENST00000396431	Q9H4L5 [Direct mapping] Oxysterol-binding protein-related protein 3 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006869 [lipid transport] GO:0015485 [cholesterol binding] GO:0016020 [membrane] GO:0031965 [nuclear membrane] GO:0097038 [perinuclear endoplasmic reticulum] Show all	856 aa 97.7 kDa	No	0
OSBPL3-003 ENSP00000379706 ENST00000396429	Q9H4L5 [Direct mapping] Oxysterol-binding protein-related protein 3 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006869 [lipid transport] GO:0015485 [cholesterol binding] GO:0016020 [membrane] GO:0031965 [nuclear membrane] GO:0097038 [perinuclear endoplasmic reticulum] Show all	851 aa 97.3 kDa	No	0
OSBPL3-006 ENSP00000386953 ENST00000409069	Q9H4L5 [Direct mapping] Oxysterol-binding protein-related protein 3 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006869 [lipid transport] GO:0015485 [cholesterol binding] GO:0016020 [membrane] GO:0031965 [nuclear membrane] GO:0097038 [perinuclear endoplasmic reticulum] Show all	820 aa 93.8 kDa	No	0
OSBPL3-009 ENSP00000407829 ENST00000415162	C9JZ19 [Direct mapping] Oxysterol-binding protein-related protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		112 aa 12.8 kDa	No	0
OSBPL3-010 ENSP00000403374 ENST00000441059	C9JEF2 [Direct mapping] Oxysterol-binding protein-related protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		89 aa 10.3 kDa	No	0
OSBPL3-015 ENSP00000411249 ENST00000415952	C9J8P4 [Direct mapping] Oxysterol-binding protein-related protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		61 aa 6.8 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.