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NCK2

GENERAL INFORMATION

Gene name

 NCK2

Gene description

 NCK adaptor protein 2

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and membranous expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA031004 , CAB016116
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 NCK2 (HGNC Symbol)

Synonyms

 NCKbeta

Description

 NCK adaptor protein 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the NCK family of adaptor proteins. The protein contains three SH3 domains and one SH2 domain. The protein has no known catalytic function but has been shown to bind and recruit various proteins involved in the regulation of receptor protein tyrosine kinases. It is through these regulatory activities that this protein is believed to be involved in cytoskeletal reorganization. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 q12.2

Chromosome location (bp)

 105744897 - 105894274

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000071051 (version 83.38)

Entrez gene

 8440

UniProt

 O43639 (UniProt - Evidence at protein level)

neXtProt

 NX_O43639

Antibodypedia

 NCK2 antibodies

PROTEIN BROWSER
NCK2-001
NCK2-002
NCK2-003
NCK2-004
NCK2-005
NCK2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NCK2-001
ENSP00000233154
ENST00000233154
O43639 [Direct mapping]
Cytoplasmic protein NCK2
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001771 [immunological synapse formation]
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0007015 [actin filament organization]
GO:0007165 [signal transduction]
GO:0007172 [signal complex assembly]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007176 [regulation of epidermal growth factor-activated receptor activity]
GO:0007411 [axon guidance]
GO:0008093 [cytoskeletal adaptor activity]
GO:0008285 [negative regulation of cell proliferation]
GO:0012506 [vesicle membrane]
GO:0016477 [cell migration]
GO:0030032 [lamellipodium assembly]
GO:0030159 [receptor signaling complex scaffold activity]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0032403 [protein complex binding]
GO:0033137 [negative regulation of peptidyl-serine phosphorylation]
GO:0036493 [positive regulation of translation in response to endoplasmic reticulum stress]
GO:0042102 [positive regulation of T cell proliferation]
GO:0042110 [T cell activation]
GO:0045202 [synapse]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0060996 [dendritic spine development]
GO:0097110 [scaffold protein binding]
GO:0097481 [neuronal postsynaptic density]
GO:1902237 [positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway]
GO:1903898 [negative regulation of PERK-mediated unfolded protein response]
GO:1903912 [negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation]
GO:1990441 [negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress]
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 380 aa
42.9 kDa 		No 0
NCK2-002
ENSP00000377018
ENST00000393349
O43639 [Direct mapping]
Cytoplasmic protein NCK2
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0007165 [signal transduction]
GO:0007172 [signal complex assembly]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007176 [regulation of epidermal growth factor-activated receptor activity]
GO:0007411 [axon guidance]
GO:0008093 [cytoskeletal adaptor activity]
GO:0008285 [negative regulation of cell proliferation]
GO:0030159 [receptor signaling complex scaffold activity]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0033137 [negative regulation of peptidyl-serine phosphorylation]
GO:0042102 [positive regulation of T cell proliferation]
GO:0042110 [T cell activation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:1903912 [negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation]
Show all
 380 aa
42.9 kDa 		No 0
NCK2-003
ENSP00000408040
ENST00000425756
E9PEE2 [Direct mapping]
Cytoplasmic protein NCK2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 110 aa
12.6 kDa 		No 0
NCK2-004
ENSP00000377017
ENST00000393348
E7EPF5 [Direct mapping]
Cytoplasmic protein NCK2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 144 aa
16.4 kDa 		No 0
NCK2-005
ENSP00000431109
ENST00000522586
E7ERP6 [Direct mapping]
Cytoplasmic protein NCK2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 83 aa
9.8 kDa 		No 0
NCK2-201
ENSP00000410428
ENST00000451463
E7ERP6 [Direct mapping]
Cytoplasmic protein NCK2
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
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 83 aa
9.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.