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CPSF1

GENERAL INFORMATION

Gene name

 CPSF1

Gene description

 Cleavage and polyadenylation specific factor 1, 160kDa

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 CPSF1

Synonyms

Description

 Cleavage and polyadenylation specific factor 1, 160kDa (HGNC Symbol)

Entrez gene summary

 Cleavage and polyadenylation specificity factor (CPSF) is a multisubunit complex that plays a central role in 3-prime processing of pre-mRNAs. CPSF recognizes the AAUAAA signal in the pre-mRNA and interacts with other proteins to facilitate both RNA cleavage and poly(A) synthesis. CPSF1 is the largest subunit of the CPSF complex (Murthy and Manley, 1995 [PubMed 7590244]).[supplied by OMIM, Mar 2008]

Chromosome

 8

Cytoband

 q24.3

Chromosome location (bp)

 144393229 - 144409349

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000071894 (version 83.38)

Entrez gene

 29894

UniProt

 Q10570 (UniProt - Evidence at protein level)

neXtProt

 NX_Q10570

Antibodypedia

 CPSF1 antibodies

PROTEIN BROWSER
CPSF1-001
CPSF1-012
CPSF1-013
CPSF1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CPSF1-001
ENSP00000478145
ENST00000620219
Q10570 [Direct mapping]
Cleavage and polyadenylation specificity factor subunit 1
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000398 [mRNA splicing, via spliceosome]
GO:0003676 [nucleic acid binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005847 [mRNA cleavage and polyadenylation specificity factor complex]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006369 [termination of RNA polymerase II transcription]
GO:0006378 [mRNA polyadenylation]
GO:0006406 [mRNA export from nucleus]
GO:0008033 [tRNA processing]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0019899 [enzyme binding]
GO:0031124 [mRNA 3'-end processing]
GO:0035925 [mRNA 3'-UTR AU-rich region binding]
GO:0098789 [pre-mRNA cleavage required for polyadenylation]
Show all
 1443 aa
160.9 kDa 		No 0
CPSF1-012
ENSP00000483775
ENST00000531727
A0A087X101 [Direct mapping]
Cleavage and polyadenylation-specificity factor subunit 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0005634 [nucleus]
Show all
 204 aa
23.7 kDa 		No 0
CPSF1-013
ENSP00000478161
ENST00000532935
A0A087WTV4 [Direct mapping]
Cleavage and polyadenylation-specificity factor subunit 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0005634 [nucleus]
Show all
 169 aa
19.2 kDa 		No 0
CPSF1-201
ENSP00000484669
ENST00000616140
Q10570 [Direct mapping]
Cleavage and polyadenylation specificity factor subunit 1
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000398 [mRNA splicing, via spliceosome]
GO:0003676 [nucleic acid binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005847 [mRNA cleavage and polyadenylation specificity factor complex]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006369 [termination of RNA polymerase II transcription]
GO:0006378 [mRNA polyadenylation]
GO:0006406 [mRNA export from nucleus]
GO:0008033 [tRNA processing]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0019899 [enzyme binding]
GO:0031124 [mRNA 3'-end processing]
GO:0035925 [mRNA 3'-UTR AU-rich region binding]
GO:0098789 [pre-mRNA cleavage required for polyadenylation]
Show all
 1443 aa
160.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.