Tissue expression of CPSF1 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	CPSF1
Gene description	Cleavage and polyadenylation specific factor 1, 160kDa
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	CPSF1
Synonyms
Description	Cleavage and polyadenylation specific factor 1, 160kDa (HGNC Symbol)
Entrez gene summary	Cleavage and polyadenylation specificity factor (CPSF) is a multisubunit complex that plays a central role in 3-prime processing of pre-mRNAs. CPSF recognizes the AAUAAA signal in the pre-mRNA and interacts with other proteins to facilitate both RNA cleavage and poly(A) synthesis. CPSF1 is the largest subunit of the CPSF complex (Murthy and Manley, 1995 [PubMed 7590244]).[supplied by OMIM, Mar 2008]
Chromosome	8
Cytoband	q24.3
Chromosome location (bp)	144393229 - 144409349
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000071894 (version 83.38)
Entrez gene	29894
UniProt	Q10570 (UniProt - Evidence at protein level)
neXtProt	NX_Q10570
Antibodypedia	CPSF1 antibodies

PROTEIN BROWSER

CPSF1-001	CPSF1-012	CPSF1-013	CPSF1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CPSF1-001 ENSP00000478145 ENST00000620219	Q10570 [Direct mapping] Cleavage and polyadenylation specificity factor subunit 1 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000398 [mRNA splicing, via spliceosome] GO:0003676 [nucleic acid binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005847 [mRNA cleavage and polyadenylation specificity factor complex] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006369 [termination of RNA polymerase II transcription] GO:0006378 [mRNA polyadenylation] GO:0006406 [mRNA export from nucleus] GO:0008033 [tRNA processing] GO:0008380 [RNA splicing] GO:0010467 [gene expression] GO:0019899 [enzyme binding] GO:0031124 [mRNA 3'-end processing] GO:0035925 [mRNA 3'-UTR AU-rich region binding] GO:0098789 [pre-mRNA cleavage required for polyadenylation] Show all	1443 aa 160.9 kDa	No	0
CPSF1-012 ENSP00000483775 ENST00000531727	A0A087X101 [Direct mapping] Cleavage and polyadenylation-specificity factor subunit 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0005634 [nucleus] Show all	204 aa 23.7 kDa	No	0
CPSF1-013 ENSP00000478161 ENST00000532935	A0A087WTV4 [Direct mapping] Cleavage and polyadenylation-specificity factor subunit 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0005634 [nucleus] Show all	169 aa 19.2 kDa	No	0
CPSF1-201 ENSP00000484669 ENST00000616140	Q10570 [Direct mapping] Cleavage and polyadenylation specificity factor subunit 1 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000398 [mRNA splicing, via spliceosome] GO:0003676 [nucleic acid binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005847 [mRNA cleavage and polyadenylation specificity factor complex] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006369 [termination of RNA polymerase II transcription] GO:0006378 [mRNA polyadenylation] GO:0006406 [mRNA export from nucleus] GO:0008033 [tRNA processing] GO:0008380 [RNA splicing] GO:0010467 [gene expression] GO:0019899 [enzyme binding] GO:0031124 [mRNA 3'-end processing] GO:0035925 [mRNA 3'-UTR AU-rich region binding] GO:0098789 [pre-mRNA cleavage required for polyadenylation] Show all	1443 aa 160.9 kDa	No	0