Tissue expression of PDCD2 - Summary - The Human Protein Atlas

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PDCD2

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	PDCD2
Gene description	Programmed cell death 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA026713
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

N/A

Caudate

N/A

N/A

Cerebellum

N/A

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

N/A

Bronchus

N/A

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

N/A

Skin

N/A

Skin

N/A

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	PDCD2 (HGNC Symbol)
Synonyms	RP8, ZMYND7
Description	Programmed cell death 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a nuclear protein expressed in a variety of tissues. Expression of this gene has been shown to be repressed by B-cell CLL/lymphoma 6 (BCL6), a transcriptional repressor required for lymph node germinal center development, suggesting that BCL6 regulates apoptosis by its effects on this protein. Alternative splicing results in multiple transcript variants and pseudogenes have been identified on chromosomes 9 and 12. [provided by RefSeq, Dec 2010]
Chromosome	6
Cytoband	q27
Chromosome location (bp)	170575295 - 170584692
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000071994 (version 83.38)
Entrez gene	5134
UniProt	Q16342 (UniProt - Evidence at protein level)
neXtProt	NX_Q16342
Antibodypedia	PDCD2 antibodies

PROTEIN BROWSER

PDCD2-001	PDCD2-002	PDCD2-004	PDCD2-005	PDCD2-006	PDCD2-007	PDCD2-014	PDCD2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PDCD2-001 ENSP00000439467 ENST00000541970	Q16342 [Direct mapping] Programmed cell death protein 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006915 [apoptotic process] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0012501 [programmed cell death] GO:0019899 [enzyme binding] GO:0043065 [positive regulation of apoptotic process] GO:0046872 [metal ion binding] GO:0070062 [extracellular exosome] GO:1901532 [regulation of hematopoietic progenitor cell differentiation] GO:1902035 [positive regulation of hematopoietic stem cell proliferation] Show all	344 aa 38.6 kDa	No	0
PDCD2-002 ENSP00000402524 ENST00000453163	Q16342 [Direct mapping] Programmed cell death protein 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006915 [apoptotic process] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0019899 [enzyme binding] GO:0043065 [positive regulation of apoptotic process] GO:0046872 [metal ion binding] GO:0070062 [extracellular exosome] GO:1901532 [regulation of hematopoietic progenitor cell differentiation] GO:1902035 [positive regulation of hematopoietic stem cell proliferation] Show all	228 aa 25.5 kDa	No	0
PDCD2-004 ENSP00000397272 ENST00000443345	Q16342 [Direct mapping] Programmed cell death protein 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006915 [apoptotic process] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0019899 [enzyme binding] GO:0043065 [positive regulation of apoptotic process] GO:0046872 [metal ion binding] GO:0070062 [extracellular exosome] GO:1901532 [regulation of hematopoietic progenitor cell differentiation] GO:1902035 [positive regulation of hematopoietic stem cell proliferation] Show all	195 aa 22.2 kDa	No	0
PDCD2-005 ENSP00000440572 ENST00000537445	Q16342 [Direct mapping] Programmed cell death protein 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006915 [apoptotic process] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0019899 [enzyme binding] GO:0043065 [positive regulation of apoptotic process] GO:0046872 [metal ion binding] GO:0070062 [extracellular exosome] GO:1901532 [regulation of hematopoietic progenitor cell differentiation] GO:1902035 [positive regulation of hematopoietic stem cell proliferation] Show all	188 aa 21.3 kDa	No	0
PDCD2-006 ENSP00000439914 ENST00000542896	F5H4V9 [Direct mapping] Programmed cell death protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0046872 [metal ion binding] Show all	298 aa 33.5 kDa	No	0
PDCD2-007 ENSP00000375940 ENST00000392090	Q16342 [Direct mapping] Programmed cell death protein 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006915 [apoptotic process] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0019899 [enzyme binding] GO:0043065 [positive regulation of apoptotic process] GO:0046872 [metal ion binding] GO:0070062 [extracellular exosome] GO:1901532 [regulation of hematopoietic progenitor cell differentiation] GO:1902035 [positive regulation of hematopoietic stem cell proliferation] Show all	311 aa 35.3 kDa	No	0
PDCD2-014 ENSP00000442815 ENST00000538195	F5H739 [Direct mapping] Programmed cell death protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		21 aa 2.3 kDa	No	0
PDCD2-201 ENSP00000481860 ENST00000614056	A0A087WYJ3 [Direct mapping] Programmed cell death protein 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0046872 [metal ion binding] Show all	221 aa 24.6 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.