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PDCD2

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GENERAL INFORMATION

Gene name

 PDCD2

Gene description

 Programmed cell death 2

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleoplasm. In addition localized to the cytokinetic bridge.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (approved)

Additional location

 In addition localized to the Cytokinetic bridge (approved)

Single-cell variation

 Single-cell variation in protein expression observed.

Cell cycle dependency

 Cell cycle dependent expression determined by biological definition

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA075534
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleoplasm. In addition localized to the cytokinetic bridge.

Main location

 Nucleoplasm (approved)

Additional location

 Cytokinetic bridge (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA075534 HEK 293 Nucleoplasm
Cytokinetic bridge Intensity Intensity
HPA075534 Hep G2 Nucleoplasm

CELL CYCLE

Summary

 Expression has cell cycle dependency according to biological definition

Intensity variation

 Cytokinetic bridge

GENE INFORMATION

Gene name

 PDCD2 (HGNC Symbol)

Synonyms

 RP8, ZMYND7

Description

 Programmed cell death 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a nuclear protein expressed in a variety of tissues. Expression of this gene has been shown to be repressed by B-cell CLL/lymphoma 6 (BCL6), a transcriptional repressor required for lymph node germinal center development, suggesting that BCL6 regulates apoptosis by its effects on this protein. Alternative splicing results in multiple transcript variants and pseudogenes have been identified on chromosomes 9 and 12. [provided by RefSeq, Dec 2010]

Chromosome

 6

Cytoband

 q27

Chromosome location (bp)

 170575295 - 170584692

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000071994 (version 83.38)

Entrez gene

 5134

UniProt

 Q16342 (UniProt - Evidence at protein level)

neXtProt

 NX_Q16342

Antibodypedia

 PDCD2 antibodies

PROTEIN BROWSER
PDCD2-001
PDCD2-002
PDCD2-004
PDCD2-005
PDCD2-006
PDCD2-007
PDCD2-014
PDCD2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PDCD2-001
ENSP00000439467
ENST00000541970
Q16342 [Direct mapping]
Programmed cell death protein 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0012501 [programmed cell death]
GO:0019899 [enzyme binding]
GO:0043065 [positive regulation of apoptotic process]
GO:0046872 [metal ion binding]
GO:0070062 [extracellular exosome]
GO:1901532 [regulation of hematopoietic progenitor cell differentiation]
GO:1902035 [positive regulation of hematopoietic stem cell proliferation]
Show all
 344 aa
38.6 kDa 		No 0
PDCD2-002
ENSP00000402524
ENST00000453163
Q16342 [Direct mapping]
Programmed cell death protein 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0019899 [enzyme binding]
GO:0043065 [positive regulation of apoptotic process]
GO:0046872 [metal ion binding]
GO:0070062 [extracellular exosome]
GO:1901532 [regulation of hematopoietic progenitor cell differentiation]
GO:1902035 [positive regulation of hematopoietic stem cell proliferation]
Show all
 228 aa
25.5 kDa 		No 0
PDCD2-004
ENSP00000397272
ENST00000443345
Q16342 [Direct mapping]
Programmed cell death protein 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0019899 [enzyme binding]
GO:0043065 [positive regulation of apoptotic process]
GO:0046872 [metal ion binding]
GO:0070062 [extracellular exosome]
GO:1901532 [regulation of hematopoietic progenitor cell differentiation]
GO:1902035 [positive regulation of hematopoietic stem cell proliferation]
Show all
 195 aa
22.2 kDa 		No 0
PDCD2-005
ENSP00000440572
ENST00000537445
Q16342 [Direct mapping]
Programmed cell death protein 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0019899 [enzyme binding]
GO:0043065 [positive regulation of apoptotic process]
GO:0046872 [metal ion binding]
GO:0070062 [extracellular exosome]
GO:1901532 [regulation of hematopoietic progenitor cell differentiation]
GO:1902035 [positive regulation of hematopoietic stem cell proliferation]
Show all
 188 aa
21.3 kDa 		No 0
PDCD2-006
ENSP00000439914
ENST00000542896
F5H4V9 [Direct mapping]
Programmed cell death protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0046872 [metal ion binding]
Show all
 298 aa
33.5 kDa 		No 0
PDCD2-007
ENSP00000375940
ENST00000392090
Q16342 [Direct mapping]
Programmed cell death protein 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0019899 [enzyme binding]
GO:0043065 [positive regulation of apoptotic process]
GO:0046872 [metal ion binding]
GO:0070062 [extracellular exosome]
GO:1901532 [regulation of hematopoietic progenitor cell differentiation]
GO:1902035 [positive regulation of hematopoietic stem cell proliferation]
Show all
 311 aa
35.3 kDa 		No 0
PDCD2-014
ENSP00000442815
ENST00000538195
F5H739 [Direct mapping]
Programmed cell death protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 21 aa
2.3 kDa 		No 0
PDCD2-201
ENSP00000481860
ENST00000614056
A0A087WYJ3 [Direct mapping]
Programmed cell death protein 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0046872 [metal ion binding]
Show all
 221 aa
24.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.