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RPS6KA6

GENERAL INFORMATION

Gene name

 RPS6KA6

Gene description

 Ribosomal protein S6 kinase, 90kDa, polypeptide 6

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (NTERA-2, PC-3, RH-30, SH-SY5Y)
HPA (normal tissue):Tissue enhanced (parathyroid gland, thyroid gland)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic staining.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Presumed off target binding observed and disregarded. Pending external verification.

Reliability score

 Uncertain based on 2 antibodies.
HPA002852 , HPA003904
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Melanoma

STAINING SUMMARY
HPA002852
HPA003904

GENE INFORMATION

Gene name

 RPS6KA6 (HGNC Symbol)

Synonyms

 RSK4

Description

 Ribosomal protein S6 kinase, 90kDa, polypeptide 6 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of ribosomal S6 kinase family, serine-threonine protein kinases which are regulated by growth factors. The encoded protein may be distinct from other members of this family, however, as studies suggest it is not growth factor dependent and may not participate in the same signaling pathways. [provided by RefSeq, Jan 2010]

Chromosome

 X

Cytoband

 q21.1

Chromosome location (bp)

 84058346 - 84187907

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000072133 (version 83.38)

Entrez gene

 27330

UniProt

 Q9UK32 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UK32

Antibodypedia

 RPS6KA6 antibodies

PROTEIN BROWSER
RPS6KA6-001
RPS6KA6-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RPS6KA6-001
ENSP00000262752
ENST00000262752
Q9UK32 [Direct mapping]
Ribosomal protein S6 kinase alpha-6
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004711 [ribosomal protein S6 kinase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006417 [regulation of translation]
GO:0006468 [protein phosphorylation]
GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:0007165 [signal transduction]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0007417 [central nervous system development]
GO:0035556 [intracellular signal transduction]
GO:0045992 [negative regulation of embryonic development]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:2000381 [negative regulation of mesoderm development]
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 745 aa
83.9 kDa 		No 0
RPS6KA6-201
ENSP00000483896
ENST00000620340
Q9UK32 [Direct mapping]
Ribosomal protein S6 kinase alpha-6
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004711 [ribosomal protein S6 kinase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006417 [regulation of translation]
GO:0006468 [protein phosphorylation]
GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:0007165 [signal transduction]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0007417 [central nervous system development]
GO:0035556 [intracellular signal transduction]
GO:0045992 [negative regulation of embryonic development]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:2000381 [negative regulation of mesoderm development]
Show all
 745 aa
84.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.