Tissue expression of SPEG - Summary - The Human Protein Atlas

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SPEG

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	SPEG
Gene description	SPEG complex locus
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Mixed
FANTOM5:	Mixed

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic and membranous expression in several tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Caution, Splice and/or transcript discrepancy exists.
Reliability score	Approved based on 1 antibody. HPA018904
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

Skeletal muscle

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Mixed
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Mixed

GENE INFORMATION
Gene name	SPEG (HGNC Symbol)
Synonyms	APEG1, BPEG, KIAA1297, MGC12676, SPEGalpha, SPEGbeta
Description	SPEG complex locus (HGNC Symbol)
Entrez gene summary	This gene encodes a protein with similarity to members of the myosin light chain kinase family. This protein family is required for myocyte cytoskeletal development. Studies in mouse have determined that a lack of this protein affected myocardial development. Multiple alternatively spliced transcript variants have been reported for this gene, but the full-length nature of only two variants that encode different protein isoforms has been defined. [provided by RefSeq, Mar 2010]
Chromosome	2
Cytoband	q35
Chromosome location (bp)	219434846 - 219498287
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000072195 (version 83.38)
Entrez gene	10290
UniProt	Q15772 (UniProt - Evidence at protein level)
neXtProt	NX_Q15772
Antibodypedia	SPEG antibodies

PROTEIN BROWSER

SPEG-004	SPEG-006	SPEG-007	SPEG-009	SPEG-010	SPEG-013	SPEG-014	SPEG-021	SPEG-023	SPEG-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SPEG-004 ENSP00000311684 ENST00000312358	Q15772 [Direct mapping] Striated muscle preferentially expressed protein kinase Show all	Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001701 [in utero embryonic development] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0006468 [protein phosphorylation] GO:0007517 [muscle organ development] GO:0008285 [negative regulation of cell proliferation] GO:0042692 [muscle cell differentiation] GO:0055013 [cardiac muscle cell development] GO:0060541 [respiratory system development] GO:0072358 [cardiovascular system development] Show all	3267 aa 354.3 kDa	No	0
SPEG-006 ENSP00000379919 ENST00000396688	Q15772 [Direct mapping] Striated muscle preferentially expressed protein kinase Show all	Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0006468 [protein phosphorylation] GO:0007517 [muscle organ development] GO:0008285 [negative regulation of cell proliferation] Show all	113 aa 12.7 kDa	No	0
SPEG-007 ENSP00000379920 ENST00000396689	Q15772 [Direct mapping] Striated muscle preferentially expressed protein kinase Show all	Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0006468 [protein phosphorylation] GO:0007517 [muscle organ development] GO:0008285 [negative regulation of cell proliferation] Show all	113 aa 12.7 kDa	No	0
SPEG-009 ENSP00000410986 ENST00000431523	C9J8D8 [Direct mapping] Striated muscle preferentially-expressed protein kinase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		299 aa 32.4 kDa	No	0
SPEG-010 ENSP00000379917 ENST00000396686	Q15772 [Direct mapping] Striated muscle preferentially expressed protein kinase Show all	Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0006468 [protein phosphorylation] GO:0007517 [muscle organ development] GO:0008285 [negative regulation of cell proliferation] Show all	113 aa 12.7 kDa	No	0
SPEG-013 ENSP00000393134 ENST00000435853	C9JWU5 [Direct mapping] Striated muscle preferentially-expressed protein kinase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		188 aa 19.9 kDa	No	0
SPEG-014 ENSP00000379926 ENST00000396698	B9ZVR7 [Direct mapping] Striated muscle preferentially-expressed protein kinase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	858 aa 93.2 kDa	No	0
SPEG-021 ENSP00000390353 ENST00000412982	H7BZM6 [Direct mapping] Striated muscle preferentially-expressed protein kinase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	343 aa 38.3 kDa	No	0
SPEG-023 ENSP00000414549 ENST00000451076	H7C3Y5 [Direct mapping] Striated muscle preferentially-expressed protein kinase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		184 aa 19.1 kDa	No	0
SPEG-201 ENSP00000479190 ENST00000617028	A0A087WV53 [Direct mapping] Striated muscle preferentially-expressed protein kinase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	238 aa 26.1 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.