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SREBF1
  • TISSUE

  • premium

    CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

SREBF1

Gene description

Sterol regulatory element binding transcription factor 1

Protein class

Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
Transcription factors

Predicted localization

Intracellular,Membrane

Number of transcripts

7
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in several tissues, most abundant in adrenal gland.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data.

Reliability score

Uncertain based on 1 antibody.
HPA043343
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Adrenal gland

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

SREBF1 (HGNC Symbol)

Synonyms

bHLHd1, SREBP-1c, SREBP1

Description

Sterol regulatory element binding transcription factor 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

17

Cytoband

p11.2

Chromosome location (bp)

17810399 - 17837002

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000072310 (version 83.38)

Entrez gene

6720

UniProt

P36956 (UniProt - Evidence at protein level)

neXtProt

NX_P36956

Antibodypedia

SREBF1 antibodies

PROTEIN BROWSER

SREBF1-002
SREBF1-003
SREBF1-004
SREBF1-014
SREBF1-015
SREBF1-017
SREBF1-021

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SREBF1-002
ENSP00000261646
ENST00000261646
P36956 [Direct mapping]
Sterol regulatory element-binding protein 1 Processed sterol regulatory element-binding protein 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Plasma proteins
Transcription factors
   Basic domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006629 [lipid metabolic process]
GO:0007623 [circadian rhythm]
GO:0008610 [lipid biosynthetic process]
GO:0009267 [cellular response to starvation]
GO:0010867 [positive regulation of triglyceride biosynthetic process]
GO:0012507 [ER to Golgi transport vesicle membrane]
GO:0016021 [integral component of membrane]
GO:0031647 [regulation of protein stability]
GO:0032810 [sterol response element binding]
GO:0044281 [small molecule metabolic process]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046983 [protein dimerization activity]
GO:1903146 [regulation of mitophagy]
GO:1903214 [regulation of protein targeting to mitochondrion]
Show all
1147 aa
121.7 kDa
No 2
SREBF1-003
ENSP00000348069
ENST00000355815
P36956 [Direct mapping]
Sterol regulatory element-binding protein 1 Processed sterol regulatory element-binding protein 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Plasma proteins
Transcription factors
   Basic domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000139 [Golgi membrane]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003062 [regulation of heart rate by chemical signal]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006629 [lipid metabolic process]
GO:0007568 [aging]
GO:0007623 [circadian rhythm]
GO:0008203 [cholesterol metabolic process]
GO:0008286 [insulin receptor signaling pathway]
GO:0008610 [lipid biosynthetic process]
GO:0009267 [cellular response to starvation]
GO:0009749 [response to glucose]
GO:0010867 [positive regulation of triglyceride biosynthetic process]
GO:0012507 [ER to Golgi transport vesicle membrane]
GO:0014070 [response to organic cyclic compound]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019217 [regulation of fatty acid metabolic process]
GO:0019901 [protein kinase binding]
GO:0030324 [lung development]
GO:0031065 [positive regulation of histone deacetylation]
GO:0031647 [regulation of protein stability]
GO:0032094 [response to food]
GO:0032403 [protein complex binding]
GO:0032526 [response to retinoic acid]
GO:0032570 [response to progesterone]
GO:0032810 [sterol response element binding]
GO:0032869 [cellular response to insulin stimulus]
GO:0033762 [response to glucagon]
GO:0033993 [response to lipid]
GO:0042493 [response to drug]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043234 [protein complex]
GO:0043434 [response to peptide hormone]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0044281 [small molecule metabolic process]
GO:0045542 [positive regulation of cholesterol biosynthetic process]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046676 [negative regulation of insulin secretion]
GO:0046983 [protein dimerization activity]
GO:0050796 [regulation of insulin secretion]
GO:0051591 [response to cAMP]
GO:0070542 [response to fatty acid]
GO:0071398 [cellular response to fatty acid]
GO:1903146 [regulation of mitophagy]
GO:1903214 [regulation of protein targeting to mitochondrion]
Show all
1177 aa
124.6 kDa
No 2
SREBF1-004
ENSP00000379106
ENST00000395757
B5MD58 [Direct mapping]
Sterol regulatory element-binding protein 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0046983 [protein dimerization activity]
Show all
893 aa
95.9 kDa
No 2
SREBF1-014
ENSP00000466453
ENST00000486311
K7EMD1 [Direct mapping]
Sterol regulatory element-binding protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
157 aa
17.1 kDa
No 0
SREBF1-015
ENSP00000464923
ENST00000478616
K7EIW8 [Direct mapping]
Sterol regulatory element-binding protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
163 aa
17.1 kDa
No 0
SREBF1-017
ENSP00000463474
ENST00000577897
J3QLB6 [Direct mapping]
Sterol regulatory element-binding protein 1
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
66 aa
6.4 kDa
No 0
SREBF1-021
ENSP00000411516
ENST00000423161
F6V242 [Direct mapping]
Sterol regulatory element-binding protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0046983 [protein dimerization activity]
Show all
325 aa
33.2 kDa
No 0

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The Human Protein Atlas project is funded
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