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HMMR

GENERAL INFORMATION

Gene name

 HMMR

Gene description

 Hyaluronan-mediated motility receptor (RHAMM)

Protein class

 CD markers
FDA approved drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (testis)
GTEx:Tissue enhanced (testis)
FANTOM5:Tissue enhanced (appendix)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several tissues, most abundant in testis.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA040025 , CAB002433
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Nasopharynx
N/A
N/A
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (testis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (testis)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (appendix)

GENE INFORMATION

Gene name

 HMMR (HGNC Symbol)

Synonyms

 CD168, RHAMM

Description

 Hyaluronan-mediated motility receptor (RHAMM) (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is involved in cell motility. It is expressed in breast tissue and together with other proteins, it forms a complex with BRCA1 and BRCA2, thus is potentially associated with higher risk of breast cancer. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Dec 2008]

Chromosome

 5

Cytoband

 q34

Chromosome location (bp)

 163460203 - 163491945

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000072571 (version 83.38)

Entrez gene

 3161

UniProt

 O75330 (UniProt - Evidence at protein level)

neXtProt

 NX_O75330

Antibodypedia

 HMMR antibodies

PROTEIN BROWSER
HMMR-001
HMMR-002
HMMR-003
HMMR-006
HMMR-007
HMMR-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HMMR-001
ENSP00000377492
ENST00000393915
O75330 [Direct mapping]
Hyaluronan mediated motility receptor
Show all
CD markers
Predicted intracellular proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005540 [hyaluronic acid binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030212 [hyaluronan metabolic process]
GO:0030214 [hyaluronan catabolic process]
GO:0044281 [small molecule metabolic process]
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 725 aa
84.2 kDa 		No 0
HMMR-002
ENSP00000351554
ENST00000358715
O75330 [Direct mapping]
Hyaluronan mediated motility receptor
Show all
CD markers
Predicted intracellular proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005540 [hyaluronic acid binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030212 [hyaluronan metabolic process]
GO:0030214 [hyaluronan catabolic process]
GO:0044281 [small molecule metabolic process]
Show all
 724 aa
84.1 kDa 		No 0
HMMR-003
ENSP00000185942
ENST00000353866
O75330 [Direct mapping]
Hyaluronan mediated motility receptor
Show all
CD markers
Predicted intracellular proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005540 [hyaluronic acid binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030212 [hyaluronan metabolic process]
GO:0030214 [hyaluronan catabolic process]
GO:0044281 [small molecule metabolic process]
Show all
 709 aa
82.3 kDa 		No 0
HMMR-006
ENSP00000402673
ENST00000432118
O75330 [Direct mapping]
Hyaluronan mediated motility receptor
Show all
CD markers
Predicted intracellular proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005540 [hyaluronic acid binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030212 [hyaluronan metabolic process]
GO:0030214 [hyaluronan catabolic process]
GO:0044281 [small molecule metabolic process]
Show all
 638 aa
74.5 kDa 		No 0
HMMR-007
ENSP00000428481
ENST00000520345
E5RI30 [Direct mapping]
Hyaluronan mediated motility receptor
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005540 [hyaluronic acid binding]
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 102 aa
11.7 kDa 		No 0
HMMR-008
ENSP00000428406
ENST00000522094
E5RIH2 [Direct mapping]
Hyaluronan mediated motility receptor
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005540 [hyaluronic acid binding]
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 92 aa
10.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.