Expression of P4HA2 in cancer - Summary - The Human Protein Atlas

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P4HA2

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	P4HA2
Gene description	Prolyl 4-hydroxylase, alpha polypeptide II
Protein class	Disease related genes Enzymes Potential drug targets Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	15
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (U-87 MG)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Supported based on 3 antibodies. HPA016997 , HPA027824 , CAB062557
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), cervical cancer (unfavourable) and urothelial cancer (unfavourable).
Renal cancer p<0.001 Cervical cancer p<0.001 Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA016997	HPA027824	CAB062557

GENE INFORMATION
Gene name	P4HA2 (HGNC Symbol)
Synonyms	C-P4Halpha(II)
Description	Prolyl 4-hydroxylase, alpha polypeptide II (HGNC Symbol)
Entrez gene summary	This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Chromosome	5
Cytoband	q31.1
Chromosome location (bp)	132191838 - 132295315
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000072682 (version 83.38)
Entrez gene	8974
UniProt	O15460 (UniProt - Evidence at protein level)
neXtProt	NX_O15460
Antibodypedia	P4HA2 antibodies

PROTEIN BROWSER

P4HA2-001	P4HA2-002	P4HA2-003	P4HA2-004	P4HA2-005	P4HA2-009	P4HA2-010	P4HA2-011	P4HA2-014	P4HA2-015	P4HA2-016	P4HA2-017	P4HA2-018	P4HA2-201	P4HA2-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
P4HA2-001 ENSP00000384999 ENST00000401867	O15460 [Direct mapping] Prolyl 4-hydroxylase subunit alpha-2 Show all	Enzymes ENZYME proteins Oxidoreductases MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0004656 [procollagen-proline 4-dioxygenase activity] GO:0005506 [iron ion binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005783 [endoplasmic reticulum] GO:0005788 [endoplasmic reticulum lumen] GO:0009055 [electron carrier activity] GO:0016222 [procollagen-proline 4-dioxygenase complex] GO:0016491 [oxidoreductase activity] GO:0016702 [oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0018401 [peptidyl-proline hydroxylation to 4-hydroxy-L-proline] GO:0031418 [L-ascorbic acid binding] GO:0043231 [intracellular membrane-bounded organelle] GO:0055114 [oxidation-reduction process] Show all	535 aa 60.9 kDa	Yes	0
P4HA2-002 ENSP00000353772 ENST00000360568	O15460 [Direct mapping] Prolyl 4-hydroxylase subunit alpha-2 Show all	Enzymes ENZYME proteins Oxidoreductases MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004656 [procollagen-proline 4-dioxygenase activity] GO:0005506 [iron ion binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005783 [endoplasmic reticulum] GO:0005788 [endoplasmic reticulum lumen] GO:0009055 [electron carrier activity] GO:0016491 [oxidoreductase activity] GO:0016702 [oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0031418 [L-ascorbic acid binding] GO:0043231 [intracellular membrane-bounded organelle] GO:0055114 [oxidation-reduction process] Show all	533 aa 60.6 kDa	Yes	0
P4HA2-003 ENSP00000166534 ENST00000166534	O15460 [Direct mapping] Prolyl 4-hydroxylase subunit alpha-2 Show all	Enzymes ENZYME proteins Oxidoreductases MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004656 [procollagen-proline 4-dioxygenase activity] GO:0005506 [iron ion binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005783 [endoplasmic reticulum] GO:0005788 [endoplasmic reticulum lumen] GO:0009055 [electron carrier activity] GO:0016491 [oxidoreductase activity] GO:0016702 [oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0031418 [L-ascorbic acid binding] GO:0043231 [intracellular membrane-bounded organelle] GO:0055114 [oxidation-reduction process] Show all	535 aa 60.9 kDa	Yes	0
P4HA2-004 ENSP00000368379 ENST00000379086	O15460 [Direct mapping] Prolyl 4-hydroxylase subunit alpha-2 Show all	Enzymes ENZYME proteins Oxidoreductases MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004656 [procollagen-proline 4-dioxygenase activity] GO:0005506 [iron ion binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005783 [endoplasmic reticulum] GO:0005788 [endoplasmic reticulum lumen] GO:0009055 [electron carrier activity] GO:0016491 [oxidoreductase activity] GO:0016702 [oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0031418 [L-ascorbic acid binding] GO:0043231 [intracellular membrane-bounded organelle] GO:0055114 [oxidation-reduction process] Show all	533 aa 60.6 kDa	Yes	0
P4HA2-005 ENSP00000413542 ENST00000453286	C9JX45 [Direct mapping] Prolyl 4-hydroxylase subunit alpha-2 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004656 [procollagen-proline 4-dioxygenase activity] GO:0005783 [endoplasmic reticulum] GO:0016702 [oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen] GO:0019511 [peptidyl-proline hydroxylation] GO:0043231 [intracellular membrane-bounded organelle] GO:0055114 [oxidation-reduction process] Show all	153 aa 17.1 kDa	Yes	0
P4HA2-009 ENSP00000396495 ENST00000428369	C9JCP0 [Direct mapping] Prolyl 4-hydroxylase subunit alpha-2 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004656 [procollagen-proline 4-dioxygenase activity] GO:0005783 [endoplasmic reticulum] GO:0016702 [oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen] GO:0019511 [peptidyl-proline hydroxylation] GO:0043231 [intracellular membrane-bounded organelle] GO:0055114 [oxidation-reduction process] Show all	147 aa 16.5 kDa	Yes	0
P4HA2-010 ENSP00000389523 ENST00000417528	E7ENX0 [Direct mapping] Prolyl 4-hydroxylase subunit alpha-2 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004656 [procollagen-proline 4-dioxygenase activity] GO:0005783 [endoplasmic reticulum] GO:0016702 [oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen] GO:0019511 [peptidyl-proline hydroxylation] GO:0043231 [intracellular membrane-bounded organelle] GO:0055114 [oxidation-reduction process] Show all	204 aa 22.9 kDa	Yes	0
P4HA2-011 ENSP00000394953 ENST00000416053	C9JN43 [Direct mapping] Prolyl 4-hydroxylase subunit alpha-2 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004656 [procollagen-proline 4-dioxygenase activity] GO:0005783 [endoplasmic reticulum] GO:0016702 [oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen] GO:0019511 [peptidyl-proline hydroxylation] GO:0055114 [oxidation-reduction process] Show all	101 aa 11.4 kDa	Yes	0
P4HA2-014 ENSP00000391257 ENST00000431054	E7EPI9 [Direct mapping] Prolyl 4-hydroxylase subunit alpha-2 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004656 [procollagen-proline 4-dioxygenase activity] GO:0005783 [endoplasmic reticulum] GO:0016702 [oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen] GO:0019511 [peptidyl-proline hydroxylation] GO:0043231 [intracellular membrane-bounded organelle] GO:0055114 [oxidation-reduction process] Show all	236 aa 26.6 kDa	Yes	0
P4HA2-015 ENSP00000405406 ENST00000439698	E7ERI1 [Direct mapping] Prolyl 4-hydroxylase subunit alpha-2 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004656 [procollagen-proline 4-dioxygenase activity] GO:0005783 [endoplasmic reticulum] GO:0016702 [oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen] GO:0019511 [peptidyl-proline hydroxylation] GO:0043231 [intracellular membrane-bounded organelle] GO:0055114 [oxidation-reduction process] Show all	184 aa 20.6 kDa	Yes	0
P4HA2-016 ENSP00000403883 ENST00000418055	C9JIG4 [Direct mapping] Prolyl 4-hydroxylase subunit alpha-2 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004656 [procollagen-proline 4-dioxygenase activity] GO:0005783 [endoplasmic reticulum] GO:0016702 [oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen] GO:0019511 [peptidyl-proline hydroxylation] GO:0055114 [oxidation-reduction process] Show all	114 aa 12.7 kDa	Yes	0
P4HA2-017 ENSP00000378593 ENST00000395164	A8MXE0 [Direct mapping] Prolyl 4-hydroxylase subunit alpha-2 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004656 [procollagen-proline 4-dioxygenase activity] GO:0005783 [endoplasmic reticulum] GO:0016702 [oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen] GO:0019511 [peptidyl-proline hydroxylation] GO:0043231 [intracellular membrane-bounded organelle] GO:0055114 [oxidation-reduction process] Show all	167 aa 18.7 kDa	Yes	0
P4HA2-018 ENSP00000395956 ENST00000428841	C9JFJ1 [Direct mapping] Prolyl 4-hydroxylase subunit alpha-2 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		50 aa 5.8 kDa	Yes	0
P4HA2-201 ENSP00000368394 ENST00000379100	O15460 [Direct mapping] Prolyl 4-hydroxylase subunit alpha-2 Show all	Enzymes ENZYME proteins Oxidoreductases MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004656 [procollagen-proline 4-dioxygenase activity] GO:0005506 [iron ion binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005783 [endoplasmic reticulum] GO:0005788 [endoplasmic reticulum lumen] GO:0009055 [electron carrier activity] GO:0016491 [oxidoreductase activity] GO:0016702 [oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0031418 [L-ascorbic acid binding] GO:0043231 [intracellular membrane-bounded organelle] GO:0055114 [oxidation-reduction process] Show all	533 aa 60.6 kDa	Yes	0
P4HA2-202 ENSP00000368398 ENST00000379104	O15460 [Direct mapping] Prolyl 4-hydroxylase subunit alpha-2 Show all	Enzymes ENZYME proteins Oxidoreductases MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004656 [procollagen-proline 4-dioxygenase activity] GO:0005506 [iron ion binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005783 [endoplasmic reticulum] GO:0005788 [endoplasmic reticulum lumen] GO:0009055 [electron carrier activity] GO:0016491 [oxidoreductase activity] GO:0016702 [oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0031418 [L-ascorbic acid binding] GO:0043231 [intracellular membrane-bounded organelle] GO:0055114 [oxidation-reduction process] Show all	535 aa 60.9 kDa	Yes	0

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